Cargando…

Nectin ectodomain structures reveal a canonical adhesive interface

Nectins are immunoglobulin superfamily glycoproteins that mediate intercellular adhesion in many vertebrate tissues. Homophilic and heterophilic interactions between nectin family members help to mediate tissue patterning. We determined homophilic binding affinities and heterophilic specificities of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Harrison, Oliver J., Vendome, Jeremie, Brasch, Julia, Jin, Xiangshu, Hong, Soonjin, Katsamba, Phinikoula S., Ahlsen, Goran, Troyanovsky, Regina B., Troyanovsky, Sergey M., Honig, Barry, Shapiro, Lawrence
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443293/ https://www.ncbi.nlm.nih.gov/pubmed/22902367 http://dx.doi.org/10.1038/nsmb.2366

Ejemplares similares

Homophilic and Heterophilic Interactions of Type II Cadherins Identify Specificity Groups Underlying Cell-Adhesive Behavior
por: Brasch, Julia, et al.
Publicado: (2018)

The Adherens Junction: A Mosaic of Cadherin and Nectin Clusters Bundled by Actin Filaments
por: Indra, Indrajyoti, et al.
Publicado: (2013)

Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins
por: Vendome, Jeremie, et al.
Publicado: (2011)

Cadherin exits the junction by switching its adhesive bond
por: Hong, Soonjin, et al.
Publicado: (2011)

Molecular basis of sidekick-mediated cell-cell adhesion and specificity
por: Goodman, Kerry M, et al.
Publicado: (2016)

α-Catenin–mediated cadherin clustering couples cadherin and actin dynamics
por: Chen, Chi-Shuo, et al.
Publicado: (2015)

Binding to F-actin guides cadherin cluster assembly, stability, and movement
por: Hong, Soonjin, et al.
Publicado: (2013)

Family-wide Structural and Biophysical Analysis of Binding Interactions among Non-clustered δ-Protocadherins
por: Harrison, Oliver J., et al.
Publicado: (2020)

DIP/Dpr interactions and the evolutionary design of specificity in protein families
por: Sergeeva, Alina P., et al.
Publicado: (2020)

How clustered protocadherin binding specificity is tuned for neuronal self-/nonself-recognition
por: Goodman, Kerry Marie, et al.
Publicado: (2022)

Scribble, Erbin, and Lano redundantly regulate epithelial polarity and apical adhesion complex
por: Choi, Jongho, et al.
Publicado: (2019)

Afadin controls cadherin cluster stability using clathrin-independent mechanism
por: Indra, Indrajyoti, et al.
Publicado: (2014)

α-Catenin contributes to the strength of E-cadherin–p120 interactions
por: Troyanovsky, Regina B., et al.
Publicado: (2011)

Affinity requirements for control of synaptic targeting and neuronal cell survival by heterophilic IgSF cell adhesion molecules
por: Xu, Shuwa, et al.
Publicado: (2022)

Adhesive But Not Lateral E-cadherin Complexes Require Calcium and Catenins for Their Formation
por: Chitaev, Nikolai A., et al.
Publicado: (1998)

Plakophilin 3 and Par3 facilitate desmosomes’ association with the apical junctional complex
por: Indra, Indrajyoti, et al.
Publicado: (2021)

Direct Ca(2+)-dependent Heterophilic Interaction between Desmosomal Cadherins, Desmoglein and Desmocollin, Contributes to Cell–Cell Adhesion
por: Chitaev, Nikolai A., et al.
Publicado: (1997)

Tracing the evolution of nectin and nectin-like cell adhesion molecules
por: Duraivelan, Kheerthana, et al.
Publicado: (2020)

Basolateral protein Scribble binds phosphatase PP1 to establish a signaling network maintaining apicobasal polarity
por: Troyanovsky, Regina B., et al.
Publicado: (2021)

Ubiquitin-dependent regulation of a conserved DMRT protein controls sexually dimorphic synaptic connectivity and behavior
por: Bayer, Emily A, et al.
Publicado: (2020)

Plakophilin-3 Binds the Membrane and Filamentous Actin without Bundling F-Actin
por: Gupta, Jyoti, et al.
Publicado: (2023)

Transforming binding affinities from 3D to 2D with application to cadherin clustering
por: Wu, Yinghao, et al.
Publicado: (2011)

Synaptogenic activity of the axon guidance molecule Robo2 underlies hippocampal circuit function
por: Blockus, Heike, et al.
Publicado: (2021)

Nectin: an adhesion molecule involved in formation of synapses
por: Mizoguchi, Akira, et al.
Publicado: (2002)

Angiomotin: An Angiostatin Binding Protein That Regulates Endothelial Cell Migration and Tube Formation
por: Troyanovsky, Boris, et al.
Publicado: (2001)

Free Energy Perturbation Calculations of Mutation Effects on SARS-CoV-2 RBD::ACE2 Binding Affinity
por: Sergeeva, Alina P., et al.
Publicado: (2023)

Nectin Cell Adhesion Molecule 4 (NECTIN4) Expression in Cutaneous Squamous Cell Carcinoma: A New Therapeutic Target?
por: Tanaka, Yuka, et al.
Publicado: (2021)

Simple viral/minimal piggyBac hybrid vectors for stable production of self-inactivating gamma-retroviruses
por: Troyanovsky, Boris, et al.
Publicado: (2015)

Cell adhesion molecules nectins and associating proteins: Implications for physiology and pathology
por: OGITA, Hisakazu, et al.
Publicado: (2010)

The Expression of the Nectin Complex in Human Breast Cancer and the Role of Nectin-3 in the Control of Tight Junctions during Metastasis
por: Martin, Tracey A., et al.
Publicado: (2013)

The cell adhesion molecule nectin-1 is critical for normal enamel formation in mice
por: Barron, Martin J., et al.
Publicado: (2008)

Nectin expression in pancreatic adenocarcinoma: nectin-3 is associated with a poor prognosis
por: Izumi, Hideki, et al.
Publicado: (2015)

The Functionality of Minimal PiggyBac Transposons in Mammalian Cells
por: Troyanovsky, Boris, et al.
Publicado: (2016)

p63-dependent and independent mechanisms of nectin-1 and nectin-4 regulation in the epidermis
por: Mollo, Maria Rosaria, et al.
Publicado: (2015)

Diagnostic and Prognostic Roles of Urine Nectin-2 and Nectin-4 in Human Bladder Cancer
por: Miyake, Makito, et al.
Publicado: (2023)

Genetic variants in NECTIN4 encoding an adhesion molecule are associated with continued opioid use
por: Fang, Chiu-Ping, et al.
Publicado: (2020)

Con-nectin axons and dendrites
por: Beaudoin, Gerard M.J.
Publicado: (2006)

Two Cell Adhesion Molecules, Nectin and Cadherin, Interact through Their Cytoplasmic Domain–Associated Proteins
por: Tachibana, Kouichi, et al.
Publicado: (2000)

γ-Protocadherin structural diversity and functional implications
por: Goodman, Kerry Marie, et al.
Publicado: (2016)

Nectin-3 (CD113) Interacts with Nectin-2 (CD112) to Promote Lymphocyte Transendothelial Migration
por: Devilard, Elisabeth, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_qa9lp4og9u7uvhe96agje6sp9r