The first recombinant human coagulation factor VIII of human origin: human cell line and manufacturing characteristics

INTRODUCTION: Since the early 1990s, recombinant human clotting factor VIII (rhFVIII) produced in hamster cells has been available for haemophilia A treatment. However, the post-translational modifications of these proteins are not identical to those of native human FVIII, which may lead to immunoge...

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Detalles Bibliográficos
Autores principales: Casademunt, Elisabeth, Martinelle, Kristina, Jernberg, Mats, Winge, Stefan, Tiemeyer, Maya, Biesert, Lothar, Knaub, Sigurd, Walter, Olaf, Schröder, Carola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2012
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443369/
https://www.ncbi.nlm.nih.gov/pubmed/22690791
http://dx.doi.org/10.1111/j.1600-0609.2012.01804.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443369/
https://www.ncbi.nlm.nih.gov/pubmed/22690791
http://dx.doi.org/10.1111/j.1600-0609.2012.01804.x

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