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Allosteric mutants show that PrfA activation is dispensable for vacuole escape but required for efficient spread and Listeria survival in vivo

The transcriptional regulator PrfA controls key virulence determinants of the facultative intracellular pathogen Listeria monocytogenes. PrfA-dependent gene expression is strongly induced within host cells. While the basis of this activation is unknown, the structural homology of PrfA with the cAMP...

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Detalles Bibliográficos
Autores principales:	Deshayes, Caroline, Bielecka, Magdalena K, Cain, Robert J, Scortti, Mariela, de las Heras, Aitor, Pietras, Zbigniew, Luisi, Ben F, Núñez Miguel, Ricardo, Vázquez-Boland, José A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2012
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443378/ https://www.ncbi.nlm.nih.gov/pubmed/22646689 http://dx.doi.org/10.1111/j.1365-2958.2012.08121.x

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