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Gating Movement of Acetylcholine Receptor Caught by Plunge-Freezing
The nicotinic acetylcholine (ACh) receptor converts transiently to an open-channel form when activated by ACh released into the synaptic cleft. We describe here the conformational change underlying this event, determined by electron microscopy of ACh-sprayed and freeze-trapped postsynaptic membranes...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443390/ https://www.ncbi.nlm.nih.gov/pubmed/22841691 http://dx.doi.org/10.1016/j.jmb.2012.07.010 |