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Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia
Renal ischemia reperfusion injury is a major cause of acute kidney injury. We previously found that renal A1 adenosine receptor (A1AR) activation attenuated multiple cell death pathways including necrosis, apoptosis and inflammation. Here, we tested whether induction of cytoprotective sphingosine ki...
Autores principales: | Park, Sang Won, Kim, Mihwa, Kim, Joo Yun, Brown, Kevin M., Haase, Volker H., D’Agati, Vivette D., Lee, H. Thomas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443517/ https://www.ncbi.nlm.nih.gov/pubmed/22695326 http://dx.doi.org/10.1038/ki.2012.224 |
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