The solution structure of the prototype foamy virus RNase H domain indicates an important role of the basic loop in substrate binding

BACKGROUND: The ribonuclease H (RNase H) domains of retroviral reverse transcriptases play an essential role in the replication cycle of retroviruses. During reverse transcription of the viral genomic RNA, an RNA/DNA hybrid is created whose RNA strand needs to be hydrolyzed by the RNase H to enable...

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Detalles Bibliográficos
Autores principales: Leo, Berit, Schweimer, Kristian, Rösch, Paul, Hartl, Maximilian J, Wöhrl, Birgitta M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443672/
https://www.ncbi.nlm.nih.gov/pubmed/22962864
http://dx.doi.org/10.1186/1742-4690-9-73

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