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Role of Photodynamic Therapy in the Palliation of Obstructing Esophageal Cancer

BACKGROUND/AIMS: The aim of this non-randomized study was to determine the role of photodynamic therapy (PDT) in a multimodal approach for the palliation of advanced esophageal carcinoma. METHODS: Twenty consecutive patients with obstructing esophageal cancer were enrolled in this study. Each subjec...

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Detalles Bibliográficos
Autores principales: Yoon, Hyeon Young, Cheon, Young Koog, Choi, Hye Jin, Shim, Chan Sup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Internal Medicine 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443720/
https://www.ncbi.nlm.nih.gov/pubmed/23019392
http://dx.doi.org/10.3904/kjim.2012.27.3.278
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author Yoon, Hyeon Young
Cheon, Young Koog
Choi, Hye Jin
Shim, Chan Sup
author_facet Yoon, Hyeon Young
Cheon, Young Koog
Choi, Hye Jin
Shim, Chan Sup
author_sort Yoon, Hyeon Young
collection PubMed
description BACKGROUND/AIMS: The aim of this non-randomized study was to determine the role of photodynamic therapy (PDT) in a multimodal approach for the palliation of advanced esophageal carcinoma. METHODS: Twenty consecutive patients with obstructing esophageal cancer were enrolled in this study. Each subject had dysphagia, and nine could not swallow fluid. External beam radiotherapy or a self-expandable metal stent was used following PDT for dysphagia due to recurrence of the malignancy. RESULTS: At 4 weeks post-PDT, a significant improvement in the dysphagia score was observed in 90% of patients, from 2.75 ± 0.91 to 1.05 ± 0.83 (p < 0.05). Patients with recurrent dysphagia underwent stent insertion at an average of 63 days (range, 37 to 90). The rate of major complications was 10%. Two esophageal strictures occurred, which were treated by placement of a modified expandable stent across the stricture. The median survival in these cases was 7.0 ± 0.6 months. One patient that was treated with PDT and radiotherapy is alive and showed a complete tumor response. CONCLUSIONS: PDT as a multimodality treatment is safe and effective for relieving malignant esophageal obstruction with minimal complications.
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spelling pubmed-34437202012-09-27 Role of Photodynamic Therapy in the Palliation of Obstructing Esophageal Cancer Yoon, Hyeon Young Cheon, Young Koog Choi, Hye Jin Shim, Chan Sup Korean J Intern Med Original Article BACKGROUND/AIMS: The aim of this non-randomized study was to determine the role of photodynamic therapy (PDT) in a multimodal approach for the palliation of advanced esophageal carcinoma. METHODS: Twenty consecutive patients with obstructing esophageal cancer were enrolled in this study. Each subject had dysphagia, and nine could not swallow fluid. External beam radiotherapy or a self-expandable metal stent was used following PDT for dysphagia due to recurrence of the malignancy. RESULTS: At 4 weeks post-PDT, a significant improvement in the dysphagia score was observed in 90% of patients, from 2.75 ± 0.91 to 1.05 ± 0.83 (p < 0.05). Patients with recurrent dysphagia underwent stent insertion at an average of 63 days (range, 37 to 90). The rate of major complications was 10%. Two esophageal strictures occurred, which were treated by placement of a modified expandable stent across the stricture. The median survival in these cases was 7.0 ± 0.6 months. One patient that was treated with PDT and radiotherapy is alive and showed a complete tumor response. CONCLUSIONS: PDT as a multimodality treatment is safe and effective for relieving malignant esophageal obstruction with minimal complications. The Korean Association of Internal Medicine 2012-09 2012-09-01 /pmc/articles/PMC3443720/ /pubmed/23019392 http://dx.doi.org/10.3904/kjim.2012.27.3.278 Text en Copyright © 2012 The Korean Association of Internal Medicine http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yoon, Hyeon Young
Cheon, Young Koog
Choi, Hye Jin
Shim, Chan Sup
Role of Photodynamic Therapy in the Palliation of Obstructing Esophageal Cancer
title Role of Photodynamic Therapy in the Palliation of Obstructing Esophageal Cancer
title_full Role of Photodynamic Therapy in the Palliation of Obstructing Esophageal Cancer
title_fullStr Role of Photodynamic Therapy in the Palliation of Obstructing Esophageal Cancer
title_full_unstemmed Role of Photodynamic Therapy in the Palliation of Obstructing Esophageal Cancer
title_short Role of Photodynamic Therapy in the Palliation of Obstructing Esophageal Cancer
title_sort role of photodynamic therapy in the palliation of obstructing esophageal cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443720/
https://www.ncbi.nlm.nih.gov/pubmed/23019392
http://dx.doi.org/10.3904/kjim.2012.27.3.278
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