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The danger theory: 20 years later
The self–non-self theory has dominated immunology since the 1950s. In the 1990s, Matzinger and her colleagues suggested a new, competing theory, called the “danger theory.” This theory has provoked mixed acclaim: enthusiasm and criticism. Here we assess the danger theory vis-à-vis recent experimenta...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443751/ https://www.ncbi.nlm.nih.gov/pubmed/23060876 http://dx.doi.org/10.3389/fimmu.2012.00287 |
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author | Pradeu, Thomas Cooper, Edwin L. |
author_facet | Pradeu, Thomas Cooper, Edwin L. |
author_sort | Pradeu, Thomas |
collection | PubMed |
description | The self–non-self theory has dominated immunology since the 1950s. In the 1990s, Matzinger and her colleagues suggested a new, competing theory, called the “danger theory.” This theory has provoked mixed acclaim: enthusiasm and criticism. Here we assess the danger theory vis-à-vis recent experimental data on innate immunity, transplantation, cancers and tolerance to foreign entities, and try to elucidate more clearly whether danger is well defined. |
format | Online Article Text |
id | pubmed-3443751 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-34437512012-10-11 The danger theory: 20 years later Pradeu, Thomas Cooper, Edwin L. Front Immunol Immunology The self–non-self theory has dominated immunology since the 1950s. In the 1990s, Matzinger and her colleagues suggested a new, competing theory, called the “danger theory.” This theory has provoked mixed acclaim: enthusiasm and criticism. Here we assess the danger theory vis-à-vis recent experimental data on innate immunity, transplantation, cancers and tolerance to foreign entities, and try to elucidate more clearly whether danger is well defined. Frontiers Media S.A. 2012-09-17 /pmc/articles/PMC3443751/ /pubmed/23060876 http://dx.doi.org/10.3389/fimmu.2012.00287 Text en Copyright © 2012 Pradeu and Cooper. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
spellingShingle | Immunology Pradeu, Thomas Cooper, Edwin L. The danger theory: 20 years later |
title | The danger theory: 20 years later |
title_full | The danger theory: 20 years later |
title_fullStr | The danger theory: 20 years later |
title_full_unstemmed | The danger theory: 20 years later |
title_short | The danger theory: 20 years later |
title_sort | danger theory: 20 years later |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443751/ https://www.ncbi.nlm.nih.gov/pubmed/23060876 http://dx.doi.org/10.3389/fimmu.2012.00287 |
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