A Polycomb complex remains bound through DNA replication in the absence of other eukaryotic proteins

Propagation of chromatin states through DNA replication is central to epigenetic regulation and can involve recruitment of chromatin proteins to replicating chromatin through interactions with replication fork components. Here we show using a fully reconstituted T7 bacteriophage system that eukaryot...

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Detalles Bibliográficos
Autores principales: Lengsfeld, Bettina M., Berry, Kayla N., Ghosh, Sharmistha, Takahashi, Masateru, Francis, Nicole J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443814/
https://www.ncbi.nlm.nih.gov/pubmed/22993687
http://dx.doi.org/10.1038/srep00661
Descripción
Sumario:Propagation of chromatin states through DNA replication is central to epigenetic regulation and can involve recruitment of chromatin proteins to replicating chromatin through interactions with replication fork components. Here we show using a fully reconstituted T7 bacteriophage system that eukaryotic proteins are not required to tether the Polycomb complex PRC1 to templates during DNA replication. Instead, DNA binding by PRC1 can withstand passage of a simple replication fork.

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