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Recent Advances in Chemical Modification of Peptide Nucleic Acids
Peptide nucleic acid (PNA) has become an extremely powerful tool in chemistry and biology. Although PNA recognizes single-stranded nucleic acids with exceptionally high affinity and sequence selectivity, there is considerable ongoing effort to further improve properties of PNA for both fundamental s...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443988/ https://www.ncbi.nlm.nih.gov/pubmed/22991652 http://dx.doi.org/10.1155/2012/518162 |
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author | Rozners, Eriks |
author_facet | Rozners, Eriks |
author_sort | Rozners, Eriks |
collection | PubMed |
description | Peptide nucleic acid (PNA) has become an extremely powerful tool in chemistry and biology. Although PNA recognizes single-stranded nucleic acids with exceptionally high affinity and sequence selectivity, there is considerable ongoing effort to further improve properties of PNA for both fundamental science and practical applications. The present paper discusses selected recent studies that improve on cellular uptake and binding of PNA to double-stranded DNA and RNA. The focus is on chemical modifications of PNA's backbone and heterocyclic nucleobases. The paper selects representative recent studies and does not attempt to provide comprehensive coverage of the broad and vibrant field of PNA modification. |
format | Online Article Text |
id | pubmed-3443988 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34439882012-09-18 Recent Advances in Chemical Modification of Peptide Nucleic Acids Rozners, Eriks J Nucleic Acids Review Article Peptide nucleic acid (PNA) has become an extremely powerful tool in chemistry and biology. Although PNA recognizes single-stranded nucleic acids with exceptionally high affinity and sequence selectivity, there is considerable ongoing effort to further improve properties of PNA for both fundamental science and practical applications. The present paper discusses selected recent studies that improve on cellular uptake and binding of PNA to double-stranded DNA and RNA. The focus is on chemical modifications of PNA's backbone and heterocyclic nucleobases. The paper selects representative recent studies and does not attempt to provide comprehensive coverage of the broad and vibrant field of PNA modification. Hindawi Publishing Corporation 2012 2012-09-06 /pmc/articles/PMC3443988/ /pubmed/22991652 http://dx.doi.org/10.1155/2012/518162 Text en Copyright © 2012 Eriks Rozners. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Rozners, Eriks Recent Advances in Chemical Modification of Peptide Nucleic Acids |
title | Recent Advances in Chemical Modification of Peptide Nucleic Acids |
title_full | Recent Advances in Chemical Modification of Peptide Nucleic Acids |
title_fullStr | Recent Advances in Chemical Modification of Peptide Nucleic Acids |
title_full_unstemmed | Recent Advances in Chemical Modification of Peptide Nucleic Acids |
title_short | Recent Advances in Chemical Modification of Peptide Nucleic Acids |
title_sort | recent advances in chemical modification of peptide nucleic acids |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443988/ https://www.ncbi.nlm.nih.gov/pubmed/22991652 http://dx.doi.org/10.1155/2012/518162 |
work_keys_str_mv | AT roznerseriks recentadvancesinchemicalmodificationofpeptidenucleicacids |