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Transfer of Maternal Immunity to Newborns of Diabetic Mothers
This study was carried out with hyperglycemic pregnant women to investigate the transfer of antibody classes to newborns across the placenta or by colostrum and the functional activity of phagocytes in maternal blood, cord blood, and colostrum from diabetes mothers. Samples from maternal blood, cord...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444004/ https://www.ncbi.nlm.nih.gov/pubmed/22991568 http://dx.doi.org/10.1155/2012/928187 |
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author | França, Eduardo Luzía Calderon, Iracema de Mattos Paranhos Vieira, Elisa Lima Morceli, Glilciane Honorio-França, Adenilda Cristina |
author_facet | França, Eduardo Luzía Calderon, Iracema de Mattos Paranhos Vieira, Elisa Lima Morceli, Glilciane Honorio-França, Adenilda Cristina |
author_sort | França, Eduardo Luzía |
collection | PubMed |
description | This study was carried out with hyperglycemic pregnant women to investigate the transfer of antibody classes to newborns across the placenta or by colostrum and the functional activity of phagocytes in maternal blood, cord blood, and colostrum from diabetes mothers. Samples from maternal blood, cord blood, and colostrum were collected from 20 normoglycemic and 20 hyperglycemic pregnant women. We determined antibodies levels, superoxide release, phagocytosis and bactericidal activity of phagocytes. We demonstrated that IgG levels in cord blood were higher in the hyperglycemic group. IgA and IgM levels were higher in maternal than in cord blood samples. Plasma antibody levels were lower in hyper- than in normoglycemic women. The colostrum of diabetic mothers had lower IgA and IgG levels. Colostrum and maternal blood phagocytes when exposed to EPEC increased the superoxide release. Cord blood phagocytes of hyperglycemic group, independently of bacteria, had higher superoxide release. Colostrum and blood phagocytes from diabetic group exhibited some phagocytic and microbicidal activity in response to EPEC. Mononuclear phagocytes from cord blood had the lowest phagocytosis, and bactericidal activity for EPEC, regardless of glycemic status. These data showed that hyperglycemia altered IgG transfer across the placenta and decreases immunoglobulin levels in maternal blood and colostrum. |
format | Online Article Text |
id | pubmed-3444004 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34440042012-09-18 Transfer of Maternal Immunity to Newborns of Diabetic Mothers França, Eduardo Luzía Calderon, Iracema de Mattos Paranhos Vieira, Elisa Lima Morceli, Glilciane Honorio-França, Adenilda Cristina Clin Dev Immunol Research Article This study was carried out with hyperglycemic pregnant women to investigate the transfer of antibody classes to newborns across the placenta or by colostrum and the functional activity of phagocytes in maternal blood, cord blood, and colostrum from diabetes mothers. Samples from maternal blood, cord blood, and colostrum were collected from 20 normoglycemic and 20 hyperglycemic pregnant women. We determined antibodies levels, superoxide release, phagocytosis and bactericidal activity of phagocytes. We demonstrated that IgG levels in cord blood were higher in the hyperglycemic group. IgA and IgM levels were higher in maternal than in cord blood samples. Plasma antibody levels were lower in hyper- than in normoglycemic women. The colostrum of diabetic mothers had lower IgA and IgG levels. Colostrum and maternal blood phagocytes when exposed to EPEC increased the superoxide release. Cord blood phagocytes of hyperglycemic group, independently of bacteria, had higher superoxide release. Colostrum and blood phagocytes from diabetic group exhibited some phagocytic and microbicidal activity in response to EPEC. Mononuclear phagocytes from cord blood had the lowest phagocytosis, and bactericidal activity for EPEC, regardless of glycemic status. These data showed that hyperglycemia altered IgG transfer across the placenta and decreases immunoglobulin levels in maternal blood and colostrum. Hindawi Publishing Corporation 2012 2012-09-09 /pmc/articles/PMC3444004/ /pubmed/22991568 http://dx.doi.org/10.1155/2012/928187 Text en Copyright © 2012 Eduardo Luzía França et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article França, Eduardo Luzía Calderon, Iracema de Mattos Paranhos Vieira, Elisa Lima Morceli, Glilciane Honorio-França, Adenilda Cristina Transfer of Maternal Immunity to Newborns of Diabetic Mothers |
title | Transfer of Maternal Immunity to Newborns of Diabetic Mothers |
title_full | Transfer of Maternal Immunity to Newborns of Diabetic Mothers |
title_fullStr | Transfer of Maternal Immunity to Newborns of Diabetic Mothers |
title_full_unstemmed | Transfer of Maternal Immunity to Newborns of Diabetic Mothers |
title_short | Transfer of Maternal Immunity to Newborns of Diabetic Mothers |
title_sort | transfer of maternal immunity to newborns of diabetic mothers |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444004/ https://www.ncbi.nlm.nih.gov/pubmed/22991568 http://dx.doi.org/10.1155/2012/928187 |
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