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UbcH7 reactivity profile reveals Parkin and HHARI to be RING/HECT hybrids

Although the functional interaction between ubiquitin conjugating enzymes (E2s) and ubiquitin ligases (E3s) is essential in ubiquitin (Ub) signaling, the criteria that define an active E2–E3 pair are not well-established. The human E2 UbcH7 (Ube2L3) shows broad specificity for HECT-type E3s(1), but...

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Detalles Bibliográficos
Autores principales:	Wenzel, Dawn M., Lissounov, Alexei, Brzovic, Peter S., Klevit, Rachel E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444301/ https://www.ncbi.nlm.nih.gov/pubmed/21532592 http://dx.doi.org/10.1038/nature09966

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