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High mobility group B1 impairs hepatocyte regeneration in acetaminophen hepatotoxicity

BACKGROUND: Acetaminophen (APAP) overdose induces massive hepatocyte necrosis. Necrotic tissue releases high mobility group B1 (HMGB1), and HMGB1 contributes to liver injury. Even though blockade of HMGB1 does not protect against APAP-induced acute liver injury (ALI) at 9 h time point, the later tim...

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Detalles Bibliográficos
Autores principales:	Yang, Runkuan, Zhang, Shutian, Cotoia, Antonella, Oksala, Niku, Zhu, Shengtao, Tenhunen, Jyrki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444430/ https://www.ncbi.nlm.nih.gov/pubmed/22569100 http://dx.doi.org/10.1186/1471-230X-12-45

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