Cargando…

EZN-2208 (PEG-SN38) Overcomes ABCG2-Mediated Topotecan Resistance in BRCA1-Deficient Mouse Mammary Tumors

BRCA1 dysfunction in hereditary breast cancer causes defective homology-directed DNA repair and sensitivity towards DNA damaging agents like the clinically used topoisomerase I inhibitors topotecan and irinotecan. Using our conditional K14cre;Brca1(F/F);p53(F/F) mouse model, we showed previously tha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zander, Serge A. L., Sol, Wendy, Greenberger, Lee, Zhang, Yixian, van Tellingen, Olaf, Jonkers, Jos, Borst, Piet, Rottenberg, Sven
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444454/ https://www.ncbi.nlm.nih.gov/pubmed/23028879 http://dx.doi.org/10.1371/journal.pone.0045248

Ejemplares similares

Potent and sustained inhibition of HIF-1α and downstream genes by a polyethyleneglycol-SN38 conjugate, EZN-2208, results in anti-angiogenic effects
por: Sapra, Puja, et al.
Publicado: (2011)

EZN-2208 treatment suppresses chronic lymphocytic leukaemia by interfering with environmental protection and increases response to fludarabine
por: Valsecchi, Roberta, et al.
Publicado: (2020)

Phase-I trial of survivin inhibition with EZN-3042 in dogs with spontaneous lymphoma
por: Thamm, Douglas H., et al.
Publicado: (2020)

PReS-FINAL-2208: Sacroilitis with propionibacterium acnes in a child
por: Galeotti, C, et al.
Publicado: (2013)

SN38-PEG-PLGA-verapamil nanoparticles inhibit proliferation and downregulate drug transporter ABCG2 gene expression in colorectal cancer cells
por: Nagheh, Zahra, et al.
Publicado: (2017)

2208. Fibrosis Surveillance by Transient Elastography in Patients with Untreated Hepatitis C Infection
por: Adeyemi, Oluwatoyin, et al.
Publicado: (2018)

PB2208: CLUSTER ANALYSIS UNVEILS THE CLINICAL SPECTRUM OF ERDHEIM-CHESTER DISEASE
por: Tesi, Michelangelo, et al.
Publicado: (2023)

Synthesis, characterization, and evaluation of mPEG–SN38 and mPEG–PLA–SN38 micelles for cancer therapy
por: Xie, Jing, et al.
Publicado: (2016)

2208. Ten years of the Irish National Outpatient Parenteral Antimicrobial Therapy (OPAT) Registry Data
por: Reidy, Paul, et al.
Publicado: (2023)

2208: Patient satisfaction with the Michigan Surgical and Health Optimization Program (MSHOP): A mixed methods study
por: Gruca, Martin, et al.
Publicado: (2018)

2208. Rates of Medically-Attended RSV among US Adults: A Systematic Review and Meta-Analysis
por: McLaughlin, John M, et al.
Publicado: (2022)

Commentary: Periocular topotecan for retinoblastoma
por: Sharma, Minal, et al.
Publicado: (2018)

Metronomic Chemotherapy Based on Topotecan or Topotecan and Cyclophosphamide Combination (CyTo) in Advanced, Pretreated Ovarian Cancer
por: Wysocki, Piotr J., et al.
Publicado: (2023)

New trends for overcoming ABCG2/BCRP-mediated resistance to cancer therapies
por: Westover, David, et al.
Publicado: (2015)

Topotecan and Cyclophosphamide in Adults with Relapsed Sarcoma
por: Blanchette, P., et al.
Publicado: (2012)

Periocular topotecan for vitreous seeds in retinoblastoma
por: Sthapit, Purnima R, et al.
Publicado: (2018)

Improved Brain Penetration and Antitumor Efficacy of Temozolomide by Inhibition of ABCB1 and ABCG2()
por: de Gooijer, Mark C., et al.
Publicado: (2018)

Response to Comment on Malik. Which Test for Diagnosing Early Human Diabetic Neuropathy? Diabetes 2014;63:2206–2208
por: Petropoulos, Ioannis N., et al.
Publicado: (2015)

ABCG2, a novel antigen to sort luminal progenitors of BRCA1(-) breast cancer cells
por: Leccia, Felicia, et al.
Publicado: (2014)

Optimization of liposomal topotecan for use in treating neuroblastoma
por: Chernov, Lina, et al.
Publicado: (2017)

MEK inhibition as a strategy for targeting residual breast cancer cells with low DUSP4 expression
por: Rottenberg, Sven, et al.
Publicado: (2012)

Overcoming Multidrug Resistance via Photodestruction of ABCG2-Rich Extracellular Vesicles Sequestering Photosensitive Chemotherapeutics
por: Goler-Baron, Vicky, et al.
Publicado: (2012)

Development and Validation of an HPLC Method for Analysis of Topotecan in Human Cerebrospinal Fluid and Its Application in Elimination Evaluation of Topotecan after Intraventricular Injection
por: Yoshikawa, Naoki, et al.
Publicado: (2021)

The Lipophilic Purine Nucleoside—Tdp1 Inhibitor—Enhances DNA Damage Induced by Topotecan In Vitro and Potentiates the Antitumor Effect of Topotecan In Vivo
por: Chernyshova, Irina A., et al.
Publicado: (2022)

2208. Development and Evaluation of Predictive Models for Estimating Infection Susceptibility to Empiric Treatment Regimens Among Patients with Pneumonia in Intensive Care Units
por: Dewart, Courtney M, et al.
Publicado: (2019)

Relative roles of ABCG5/ABCG8 in liver and intestine
por: Wang, Jin, et al.
Publicado: (2015)

Functional Cooperativity between ABCG4 and ABCG1 Isoforms
por: Hegyi, Zoltán, et al.
Publicado: (2016)

ABCG5 and ABCG8 Are Involved in Vitamin K Transport
por: Matsuo, Michinori, et al.
Publicado: (2023)

Oral topotecan: bioavailability and effect of food co-administration
por: Herben, V M M, et al.
Publicado: (1999)

A phase I and pharmacokinetic study of intraperitoneal topotecan
por: Hofstra, L S, et al.
Publicado: (2001)

Topotecan in the treatment of relapsed small cell lung cancer
por: Quoix, Elisabeth
Publicado: (2008)

Carboplatin +/− Topotecan Ophthalmic Artery Chemosurgery for Intraocular Retinoblastoma
por: Francis, Jasmine H., et al.
Publicado: (2013)

Adverse drug reaction after intravitreal injection of topotecan
por: Narang, Subina, et al.
Publicado: (2020)

Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery
por: Fang, Yan, et al.
Publicado: (2017)

Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors
por: Bhin, Jinhyuk, et al.
Publicado: (2023)

High imatinib dose overcomes insufficient response associated with ABCG2 haplotype in chronic myelogenous leukemia patients
por: Delord, Marc, et al.
Publicado: (2013)

First-in-human Phase I study of EZN-4176, a locked nucleic acid antisense oligonucleotide to exon 4 of the androgen receptor mRNA in patients with castration-resistant prostate cancer
por: Bianchini, D, et al.
Publicado: (2013)

STM2209-STM2208 (opvAB): A Phase Variation Locus of Salmonella enterica Involved in Control of O-Antigen Chain Length
por: Cota, Ignacio, et al.
Publicado: (2012)

PB2208: CAR-T TREATMENT POST FIRST ALLO-HSCT FAILURE MAY HAVE DIFFERENT PROCESSION COMPARING TO CAR-T BEFORE ALLO-HSCT
por: wang, D., et al.
Publicado: (2022)

Sitosterolemia: Twenty Years of Discovery of the Function of ABCG5 ABCG8
por: Williams, Kori, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9hub9pdaev2cdphgqbbpmiej8o