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Stability of the Transthyretin Molecule as a Key Factor in the Interaction with A-Beta Peptide - Relevance in Alzheimer's Disease

Transthyretin (TTR) protects against A-Beta toxicity by binding the peptide thus inhibiting its aggregation. Previous work showed different TTR mutations interact differently with A-Beta, with increasing affinities correlating with decreasing amyloidogenecity of the TTR mutant; this did not impact o...

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Detalles Bibliográficos
Autores principales:	Ribeiro, Carlos A., Saraiva, Maria João, Cardoso, Isabel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444465/ https://www.ncbi.nlm.nih.gov/pubmed/23028965 http://dx.doi.org/10.1371/journal.pone.0045368

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