MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status

The methylation status of the O(6)-methylguanine-DNA methyltransferase (MGMT) gene is an important predictive biomarker for benefit from alkylating agent therapy in glioblastoma. Recent studies in anaplastic glioma suggest a prognostic value for MGMT methylation. Investigation of pathogenetic and ep...

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Detalles Bibliográficos
Autores principales: Bady, Pierre, Sciuscio, Davide, Diserens, Annie-Claire, Bloch, Jocelyne, van den Bent, Martin J., Marosi, Christine, Dietrich, Pierre-Yves, Weller, Michael, Mariani, Luigi, Heppner, Frank L., Mcdonald, David R., Lacombe, Denis, Stupp, Roger, Delorenzi, Mauro, Hegi, Monika E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444709/
https://www.ncbi.nlm.nih.gov/pubmed/22810491
http://dx.doi.org/10.1007/s00401-012-1016-2

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