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Investigating dynamical deformations of tumor cells in circulation: predictions from a theoretical model

It is inevitable for tumor cells to deal with various mechanical forces in order to move from primary to metastatic sites. In particular, the circulating tumor cells that have detached from the primary tumor and entered into the bloodstream need to survive in a completely new microenvironment. They...

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Autor principal: Rejniak, Katarzyna A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444760/
https://www.ncbi.nlm.nih.gov/pubmed/23024961
http://dx.doi.org/10.3389/fonc.2012.00111
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author Rejniak, Katarzyna A.
author_facet Rejniak, Katarzyna A.
author_sort Rejniak, Katarzyna A.
collection PubMed
description It is inevitable for tumor cells to deal with various mechanical forces in order to move from primary to metastatic sites. In particular, the circulating tumor cells that have detached from the primary tumor and entered into the bloodstream need to survive in a completely new microenvironment. They must withstand hemodynamic forces and overcome the effects of fluid shear before they can leave the vascular system (extravasate) to establish new metastatic foci. One of the hypotheses of the tumor cell extravasation process is based on the so called “adhesion cascade” that was formulated and observed in the context of leukocytes circulating in the vascular system. During this process, the cell needs to switch between various locomotion strategies, from floating with the blood stream, to rolling on the endothelial wall, to tumor cell arrest and crawling, and finally tumor cell transmigration through the endothelial layer. The goal of this project is to use computational mechanical modeling to investigate the fundamental biophysical parameters of tumor cells in circulation. As a first step to build a robust in silico model, we consider a single cell exposed to the blood flow. We examine parameters related to structure of the actin network, cell nucleus and adhesion links between the tumor and endothelial cells that allow for successful transition between different transport modes of the adhesion cascade.
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spelling pubmed-34447602012-09-28 Investigating dynamical deformations of tumor cells in circulation: predictions from a theoretical model Rejniak, Katarzyna A. Front Oncol Oncology It is inevitable for tumor cells to deal with various mechanical forces in order to move from primary to metastatic sites. In particular, the circulating tumor cells that have detached from the primary tumor and entered into the bloodstream need to survive in a completely new microenvironment. They must withstand hemodynamic forces and overcome the effects of fluid shear before they can leave the vascular system (extravasate) to establish new metastatic foci. One of the hypotheses of the tumor cell extravasation process is based on the so called “adhesion cascade” that was formulated and observed in the context of leukocytes circulating in the vascular system. During this process, the cell needs to switch between various locomotion strategies, from floating with the blood stream, to rolling on the endothelial wall, to tumor cell arrest and crawling, and finally tumor cell transmigration through the endothelial layer. The goal of this project is to use computational mechanical modeling to investigate the fundamental biophysical parameters of tumor cells in circulation. As a first step to build a robust in silico model, we consider a single cell exposed to the blood flow. We examine parameters related to structure of the actin network, cell nucleus and adhesion links between the tumor and endothelial cells that allow for successful transition between different transport modes of the adhesion cascade. Frontiers Research Foundation 2012-09-18 /pmc/articles/PMC3444760/ /pubmed/23024961 http://dx.doi.org/10.3389/fonc.2012.00111 Text en Copyright © Rejniak. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) , which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Oncology
Rejniak, Katarzyna A.
Investigating dynamical deformations of tumor cells in circulation: predictions from a theoretical model
title Investigating dynamical deformations of tumor cells in circulation: predictions from a theoretical model
title_full Investigating dynamical deformations of tumor cells in circulation: predictions from a theoretical model
title_fullStr Investigating dynamical deformations of tumor cells in circulation: predictions from a theoretical model
title_full_unstemmed Investigating dynamical deformations of tumor cells in circulation: predictions from a theoretical model
title_short Investigating dynamical deformations of tumor cells in circulation: predictions from a theoretical model
title_sort investigating dynamical deformations of tumor cells in circulation: predictions from a theoretical model
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444760/
https://www.ncbi.nlm.nih.gov/pubmed/23024961
http://dx.doi.org/10.3389/fonc.2012.00111
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