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Patterns and Possible Roles of LINE-1 Methylation Changes in Smoke-Exposed Epithelia
Tobacco smoking and reduced methylation of long interspersed element-1 (LINE-1) are crucial in oral carcinogenesis. 5′UTR of human LINE-1 sequence contains several CpG dinucleotides which are methylated in various proportions (0–100%). Methylation levels of many LINE-1s in cancer were reduced, hypom...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445447/ https://www.ncbi.nlm.nih.gov/pubmed/23028911 http://dx.doi.org/10.1371/journal.pone.0045292 |