Loss of Expression and Function of SOCS3 Is an Early Event in HNSCC: Altered Subcellular Localization as a Possible Mechanism Involved in Proliferation, Migration and Invasion

BACKGROUND: Suppressor of cytokine signaling 3 (SOCS3) is an inducible endogenous negative regulator of signal transduction and activator of transcription 3 (STAT3). Epigenetic silencing of SOCS3 has been shown in head and neck squamous cell carcinoma (HNSCC), which is associated with increased acti...

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Detalles Bibliográficos
Autores principales: Rossa, Carlos, Sommer, Gunhild, Spolidorio, Luis C., Rosenzweig, Steven A., Watson, Dennis K., Kirkwood, Keith L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445460/
https://www.ncbi.nlm.nih.gov/pubmed/23028842
http://dx.doi.org/10.1371/journal.pone.0045197

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