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An Il12-Il2-Antibody Fusion Protein Targeting Hodgkin's Lymphoma Cells Potentiates Activation Of Nk And T Cells For An Anti-Tumor Attack

Successful immunotherapy of Hodgkin's disease is so far hampered by the striking unresponsiveness of lymphoma infiltrating immune cells. To mobilize both adoptive and innate immune cells for an anti-tumor attack we fused the pro-inflammatory cytokines IL2 and IL12 to an anti-CD30 scFv antibody...

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Detalles Bibliográficos
Autores principales:	Jahn, Tobias, Zuther, Martin, Friedrichs, Björn, Heuser, Claudia, Guhlke, Stefan, Abken, Hinrich, Hombach, Andreas A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445545/ https://www.ncbi.nlm.nih.gov/pubmed/23028547 http://dx.doi.org/10.1371/journal.pone.0044482

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