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Biochemical Characterization and Cellular Effects of CADASIL Mutants of NOTCH3

Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is the best understood cause of dominantly inherited stroke and results from NOTCH3 mutations that lead to NOTCH3 protein accumulation and selective arterial smooth muscle degeneration. Previous stud...

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Detalles Bibliográficos
Autores principales:	Meng, He, Zhang, Xiaojie, Yu, Genggeng, Lee, Soo Jung, Chen, Y. Eugene, Prudovsky, Igor, Wang, Michael M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445613/ https://www.ncbi.nlm.nih.gov/pubmed/23028706 http://dx.doi.org/10.1371/journal.pone.0044964

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