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Differential effects of the changes of LDL cholesterol and systolic blood pressure on the risk of carotid artery atherosclerosis

BACKGROUND: The effects of baseline and changes in blood pressure and low density lipoprotein (LDL) cholesterol on the carotid intima media thickness (IMT) have not been well documented. METHODS: A total of 2572 adults (mean age 53.8 years, 54.6% women) in a Taiwanese community undertook three blood...

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Autores principales: Chien, Kuo-Liong, Tu, Yu-Kang, Hsu, Hsiu-Ching, Su, Ta-Chen, Lin, Hung-Ju, Chen, Ming-Fong, Lee, Yuan-Teh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445849/
https://www.ncbi.nlm.nih.gov/pubmed/22900906
http://dx.doi.org/10.1186/1471-2261-12-66
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author Chien, Kuo-Liong
Tu, Yu-Kang
Hsu, Hsiu-Ching
Su, Ta-Chen
Lin, Hung-Ju
Chen, Ming-Fong
Lee, Yuan-Teh
author_facet Chien, Kuo-Liong
Tu, Yu-Kang
Hsu, Hsiu-Ching
Su, Ta-Chen
Lin, Hung-Ju
Chen, Ming-Fong
Lee, Yuan-Teh
author_sort Chien, Kuo-Liong
collection PubMed
description BACKGROUND: The effects of baseline and changes in blood pressure and low density lipoprotein (LDL) cholesterol on the carotid intima media thickness (IMT) have not been well documented. METHODS: A total of 2572 adults (mean age 53.8 years, 54.6% women) in a Taiwanese community undertook three blood pressure and LDL cholesterol examinations over 6 years. Latent growth curve modeling was used to investigate the effects of baseline and change in blood pressure and LDL cholesterol on IMT. RESULTS: Greater baseline LDL and blood pressure were associated with an increase in IMT (0.005 ± 0.002 mm per 1 mg/dL [p = 0.006] and 0.041 ± 0.004 mm mmHg [p <0.0001], respectively. Change in blood pressure was associated with a significant increase in IMT (0.047±0.016, P = 0.004), whilst the association between change in LDL and change in IMT was not statistically significant (0.008±0.006, P = 0.20). CONCLUSIONS: Carotid IMT was associated with baseline blood pressure and LDL cholesterol, yet only changes of blood pressure, not LDL cholesterol, were related to carotid IMT during the 6-year observation.
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spelling pubmed-34458492012-09-20 Differential effects of the changes of LDL cholesterol and systolic blood pressure on the risk of carotid artery atherosclerosis Chien, Kuo-Liong Tu, Yu-Kang Hsu, Hsiu-Ching Su, Ta-Chen Lin, Hung-Ju Chen, Ming-Fong Lee, Yuan-Teh BMC Cardiovasc Disord Research Article BACKGROUND: The effects of baseline and changes in blood pressure and low density lipoprotein (LDL) cholesterol on the carotid intima media thickness (IMT) have not been well documented. METHODS: A total of 2572 adults (mean age 53.8 years, 54.6% women) in a Taiwanese community undertook three blood pressure and LDL cholesterol examinations over 6 years. Latent growth curve modeling was used to investigate the effects of baseline and change in blood pressure and LDL cholesterol on IMT. RESULTS: Greater baseline LDL and blood pressure were associated with an increase in IMT (0.005 ± 0.002 mm per 1 mg/dL [p = 0.006] and 0.041 ± 0.004 mm mmHg [p <0.0001], respectively. Change in blood pressure was associated with a significant increase in IMT (0.047±0.016, P = 0.004), whilst the association between change in LDL and change in IMT was not statistically significant (0.008±0.006, P = 0.20). CONCLUSIONS: Carotid IMT was associated with baseline blood pressure and LDL cholesterol, yet only changes of blood pressure, not LDL cholesterol, were related to carotid IMT during the 6-year observation. BioMed Central 2012-08-17 /pmc/articles/PMC3445849/ /pubmed/22900906 http://dx.doi.org/10.1186/1471-2261-12-66 Text en Copyright ©2012 Chien et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chien, Kuo-Liong
Tu, Yu-Kang
Hsu, Hsiu-Ching
Su, Ta-Chen
Lin, Hung-Ju
Chen, Ming-Fong
Lee, Yuan-Teh
Differential effects of the changes of LDL cholesterol and systolic blood pressure on the risk of carotid artery atherosclerosis
title Differential effects of the changes of LDL cholesterol and systolic blood pressure on the risk of carotid artery atherosclerosis
title_full Differential effects of the changes of LDL cholesterol and systolic blood pressure on the risk of carotid artery atherosclerosis
title_fullStr Differential effects of the changes of LDL cholesterol and systolic blood pressure on the risk of carotid artery atherosclerosis
title_full_unstemmed Differential effects of the changes of LDL cholesterol and systolic blood pressure on the risk of carotid artery atherosclerosis
title_short Differential effects of the changes of LDL cholesterol and systolic blood pressure on the risk of carotid artery atherosclerosis
title_sort differential effects of the changes of ldl cholesterol and systolic blood pressure on the risk of carotid artery atherosclerosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445849/
https://www.ncbi.nlm.nih.gov/pubmed/22900906
http://dx.doi.org/10.1186/1471-2261-12-66
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