Cargando…

Serum Interleukin 8 Level as a Diagnostic Marker in Late Neonatal Sepsis

OBJECTIVE: Late-onset sepsis is responsible for high morbidity and mortality in newborn infants in the world and in particular in developing countries. In this study, we evaluated whether clinical characteristics, laboratory parameters and measurements of serum interleukin-8 (IL-8) are able to discr...

Descripción completa

Detalles Bibliográficos
Autores principales: Boskabadi, Hassan, Maamouri, Gholamali, afshari, Jalil Tavakol, Ghayour-Mobarhan, Majid, Shakeri, Mohammad-Taghy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446011/
https://www.ncbi.nlm.nih.gov/pubmed/23056680
_version_ 1782243885522616320
author Boskabadi, Hassan
Maamouri, Gholamali
afshari, Jalil Tavakol
Ghayour-Mobarhan, Majid
Shakeri, Mohammad-Taghy
author_facet Boskabadi, Hassan
Maamouri, Gholamali
afshari, Jalil Tavakol
Ghayour-Mobarhan, Majid
Shakeri, Mohammad-Taghy
author_sort Boskabadi, Hassan
collection PubMed
description OBJECTIVE: Late-onset sepsis is responsible for high morbidity and mortality in newborn infants in the world and in particular in developing countries. In this study, we evaluated whether clinical characteristics, laboratory parameters and measurements of serum interleukin-8 (IL-8) are able to discriminate between late neonatal sepsis and normal baby. METHODS: This was a prospective (case-control) study conducted between March 2007 and April 2008, at the neonatal intensive care unit, Ghaem Hospital, Mashhad, Iran. The study comprised 93 neonates ≥72 hours of life. The infants were categorized in two groups based on the clinical presentation, and biochemical markers including complete blood count, C-reactive protein (CRP) and blood culture: 1) Control group including 42 infants with routine screening and 2) Case group consisting of 38 infants with definitive infection (positive blood and/or cerebrospinal fluid culture) or clinical sepsis (clinical and laboratory signs of infection without positive blood or CSF culture). Receiver-operating characteristic curves were used for the determination of thresholds for the infection group versus healthy neonate group. FINDINGS: Eighty infants were enrolled in this study. IL-8 and CRP decreased in order of definitive infection, clinical sepsis and healthy subjects respectively (P<0.001). Sensitivity, specificity, positive predictive value, negative predictive value for serum levels were 0.95, 0.1, 0.97, 0.1 for IL-8 and 0.83, 0.86, 0.83, 0.69 for CRP respectively (cut-off point for IL-8 >60pg/ml and for CRP>6mg/dl). CONCLUSION: IL-8 may be a valid and early predictive marker of neonatal infection. Also, IL-8 is associated with severity of infection.
format Online
Article
Text
id pubmed-3446011
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Tehran University of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-34460112012-10-09 Serum Interleukin 8 Level as a Diagnostic Marker in Late Neonatal Sepsis Boskabadi, Hassan Maamouri, Gholamali afshari, Jalil Tavakol Ghayour-Mobarhan, Majid Shakeri, Mohammad-Taghy Iran J Pediatr Original Article OBJECTIVE: Late-onset sepsis is responsible for high morbidity and mortality in newborn infants in the world and in particular in developing countries. In this study, we evaluated whether clinical characteristics, laboratory parameters and measurements of serum interleukin-8 (IL-8) are able to discriminate between late neonatal sepsis and normal baby. METHODS: This was a prospective (case-control) study conducted between March 2007 and April 2008, at the neonatal intensive care unit, Ghaem Hospital, Mashhad, Iran. The study comprised 93 neonates ≥72 hours of life. The infants were categorized in two groups based on the clinical presentation, and biochemical markers including complete blood count, C-reactive protein (CRP) and blood culture: 1) Control group including 42 infants with routine screening and 2) Case group consisting of 38 infants with definitive infection (positive blood and/or cerebrospinal fluid culture) or clinical sepsis (clinical and laboratory signs of infection without positive blood or CSF culture). Receiver-operating characteristic curves were used for the determination of thresholds for the infection group versus healthy neonate group. FINDINGS: Eighty infants were enrolled in this study. IL-8 and CRP decreased in order of definitive infection, clinical sepsis and healthy subjects respectively (P<0.001). Sensitivity, specificity, positive predictive value, negative predictive value for serum levels were 0.95, 0.1, 0.97, 0.1 for IL-8 and 0.83, 0.86, 0.83, 0.69 for CRP respectively (cut-off point for IL-8 >60pg/ml and for CRP>6mg/dl). CONCLUSION: IL-8 may be a valid and early predictive marker of neonatal infection. Also, IL-8 is associated with severity of infection. Tehran University of Medical Sciences 2010-03 /pmc/articles/PMC3446011/ /pubmed/23056680 Text en © 2010 Iranian Journal of Pediatrics & Tehran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Boskabadi, Hassan
Maamouri, Gholamali
afshari, Jalil Tavakol
Ghayour-Mobarhan, Majid
Shakeri, Mohammad-Taghy
Serum Interleukin 8 Level as a Diagnostic Marker in Late Neonatal Sepsis
title Serum Interleukin 8 Level as a Diagnostic Marker in Late Neonatal Sepsis
title_full Serum Interleukin 8 Level as a Diagnostic Marker in Late Neonatal Sepsis
title_fullStr Serum Interleukin 8 Level as a Diagnostic Marker in Late Neonatal Sepsis
title_full_unstemmed Serum Interleukin 8 Level as a Diagnostic Marker in Late Neonatal Sepsis
title_short Serum Interleukin 8 Level as a Diagnostic Marker in Late Neonatal Sepsis
title_sort serum interleukin 8 level as a diagnostic marker in late neonatal sepsis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446011/
https://www.ncbi.nlm.nih.gov/pubmed/23056680
work_keys_str_mv AT boskabadihassan seruminterleukin8levelasadiagnosticmarkerinlateneonatalsepsis
AT maamourigholamali seruminterleukin8levelasadiagnosticmarkerinlateneonatalsepsis
AT afsharijaliltavakol seruminterleukin8levelasadiagnosticmarkerinlateneonatalsepsis
AT ghayourmobarhanmajid seruminterleukin8levelasadiagnosticmarkerinlateneonatalsepsis
AT shakerimohammadtaghy seruminterleukin8levelasadiagnosticmarkerinlateneonatalsepsis