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An Estimation of Steroid Responsiveness of Idiopathic Nephrotic Syndrome in Iranian Children

OBJECTIVE: Idiopathic Nephrotic syndrome (INS) is the most common form of nephrotic syndrome (NS) in children with the potential of progression to end stage renal disease (ESRD). INS is steroid-responsive in most children, but not all patients respond to it. The aim of this study was to determine th...

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Autores principales: Madani, Abbas, Fahimi, Darioush, Taghaodi, Rambod, Mahjoob, Fatemeh, Hajizadeh, Niloofar, Navabi, Behdad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446018/
https://www.ncbi.nlm.nih.gov/pubmed/23056704
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author Madani, Abbas
Fahimi, Darioush
Taghaodi, Rambod
Mahjoob, Fatemeh
Hajizadeh, Niloofar
Navabi, Behdad
author_facet Madani, Abbas
Fahimi, Darioush
Taghaodi, Rambod
Mahjoob, Fatemeh
Hajizadeh, Niloofar
Navabi, Behdad
author_sort Madani, Abbas
collection PubMed
description OBJECTIVE: Idiopathic Nephrotic syndrome (INS) is the most common form of nephrotic syndrome (NS) in children with the potential of progression to end stage renal disease (ESRD). INS is steroid-responsive in most children, but not all patients respond to it. The aim of this study was to determine the rate of steroid responsiveness in children with INS that referred to Children's Medical Center since 1995 to 2007. METHODS: In as a cross sectional study, the medical records of all children with INS aged 1 to 15 years who were referred to our referral hospital was reviewed. All patients with onset of disease less than 1 year of age, spontaneous remission, secondary forms of NS associated with systemic diseases, and follow up duration of less than 12 months were excluded from the study. Patients were categorized into 6 groups: Group 1 needed biopsy prior to any treatment, group 2 non-relapsing NS, group 3 infrequently relapsing NS, Group 4 frequently relapsing NS, group 5 steroid dependent NS and group 6 steroid resistant NS. FINDINGS: A total of 238 patients were enrolled in the study. Kidney biopsy was performed in 79 cases. Minimal change lesion (MCL) was the most common (36.7%) pathological diagnosis. Steroid responsiveness was found in 81.5% of all cases including: 96% of MCL (consisting of biopsy proven cases and presumed ones), 32% of focal and segmental glomerulosclerosis, 73% of diffuse mesangial proliferation and 58% of membranoproliferative glomerulonephritis patients. During minimal follow up period of 12 months, there were 194 patients in remission, 32 patients with active NS, and 12 patients in ESRD. CONCLUSION: Our study results showed that 81.5% of all patients, 96.2% of MCL and 32% of FSGS patients initially responded to steroid therapy.
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spelling pubmed-34460182012-10-09 An Estimation of Steroid Responsiveness of Idiopathic Nephrotic Syndrome in Iranian Children Madani, Abbas Fahimi, Darioush Taghaodi, Rambod Mahjoob, Fatemeh Hajizadeh, Niloofar Navabi, Behdad Iran J Pediatr Original Article OBJECTIVE: Idiopathic Nephrotic syndrome (INS) is the most common form of nephrotic syndrome (NS) in children with the potential of progression to end stage renal disease (ESRD). INS is steroid-responsive in most children, but not all patients respond to it. The aim of this study was to determine the rate of steroid responsiveness in children with INS that referred to Children's Medical Center since 1995 to 2007. METHODS: In as a cross sectional study, the medical records of all children with INS aged 1 to 15 years who were referred to our referral hospital was reviewed. All patients with onset of disease less than 1 year of age, spontaneous remission, secondary forms of NS associated with systemic diseases, and follow up duration of less than 12 months were excluded from the study. Patients were categorized into 6 groups: Group 1 needed biopsy prior to any treatment, group 2 non-relapsing NS, group 3 infrequently relapsing NS, Group 4 frequently relapsing NS, group 5 steroid dependent NS and group 6 steroid resistant NS. FINDINGS: A total of 238 patients were enrolled in the study. Kidney biopsy was performed in 79 cases. Minimal change lesion (MCL) was the most common (36.7%) pathological diagnosis. Steroid responsiveness was found in 81.5% of all cases including: 96% of MCL (consisting of biopsy proven cases and presumed ones), 32% of focal and segmental glomerulosclerosis, 73% of diffuse mesangial proliferation and 58% of membranoproliferative glomerulonephritis patients. During minimal follow up period of 12 months, there were 194 patients in remission, 32 patients with active NS, and 12 patients in ESRD. CONCLUSION: Our study results showed that 81.5% of all patients, 96.2% of MCL and 32% of FSGS patients initially responded to steroid therapy. Tehran University of Medical Sciences 2010-06 /pmc/articles/PMC3446018/ /pubmed/23056704 Text en © 2010 Iranian Journal of Pediatrics & Tehran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Madani, Abbas
Fahimi, Darioush
Taghaodi, Rambod
Mahjoob, Fatemeh
Hajizadeh, Niloofar
Navabi, Behdad
An Estimation of Steroid Responsiveness of Idiopathic Nephrotic Syndrome in Iranian Children
title An Estimation of Steroid Responsiveness of Idiopathic Nephrotic Syndrome in Iranian Children
title_full An Estimation of Steroid Responsiveness of Idiopathic Nephrotic Syndrome in Iranian Children
title_fullStr An Estimation of Steroid Responsiveness of Idiopathic Nephrotic Syndrome in Iranian Children
title_full_unstemmed An Estimation of Steroid Responsiveness of Idiopathic Nephrotic Syndrome in Iranian Children
title_short An Estimation of Steroid Responsiveness of Idiopathic Nephrotic Syndrome in Iranian Children
title_sort estimation of steroid responsiveness of idiopathic nephrotic syndrome in iranian children
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446018/
https://www.ncbi.nlm.nih.gov/pubmed/23056704
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