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Study on Efficacy of Hepatitis B Immunization in Vaccinated Beta-thalassemia Children in Tehran
OBJECTIVE: In thalassemic children, HBV infection is common, thus immunization against HBV will reduce and prevent the rate of infection. The aim of this study was to evaluate the efficacy of HBV immunization and the prevalence of HBV infection in beta-thalassemic children in Tehran. METHODS: To ass...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tehran University of Medical Sciences
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446027/ https://www.ncbi.nlm.nih.gov/pubmed/23056706 |
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author | Sharifi, Zohreh Milani, Saeideh Shooshtari, Mahmood Mahmoodian |
author_facet | Sharifi, Zohreh Milani, Saeideh Shooshtari, Mahmood Mahmoodian |
author_sort | Sharifi, Zohreh |
collection | PubMed |
description | OBJECTIVE: In thalassemic children, HBV infection is common, thus immunization against HBV will reduce and prevent the rate of infection. The aim of this study was to evaluate the efficacy of HBV immunization and the prevalence of HBV infection in beta-thalassemic children in Tehran. METHODS: To assess the efficacy of immunization and determine the immune response of children with beta-thalassemia, sera of 99 children who had received three doses (10/20 µg) of recombinant HBV vaccine in months 0, 1, 6, were selected and tested for HBsAg, HBsAb and anti-HBc by ELISA method. Also, these sera were tested for HBV DNA using nested-PCR method. FINDINGS: In 99 beta-thalassemic children, 89 (89.9 %) were anti-HBs positive (responders) and 10 (10.1%) anti-HBs negative (non-responders). 3 (3.03%) were anti-HBc positive and 1(1.01%) was HBsAg positive. HBV DNA was not detected in any of them. CONCLUSION: Our results have revealed that hepatitis B vaccine is highly immunogenic for thalassemic children and particularly well tolerated. |
format | Online Article Text |
id | pubmed-3446027 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Tehran University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-34460272012-10-09 Study on Efficacy of Hepatitis B Immunization in Vaccinated Beta-thalassemia Children in Tehran Sharifi, Zohreh Milani, Saeideh Shooshtari, Mahmood Mahmoodian Iran J Pediatr Original Article OBJECTIVE: In thalassemic children, HBV infection is common, thus immunization against HBV will reduce and prevent the rate of infection. The aim of this study was to evaluate the efficacy of HBV immunization and the prevalence of HBV infection in beta-thalassemic children in Tehran. METHODS: To assess the efficacy of immunization and determine the immune response of children with beta-thalassemia, sera of 99 children who had received three doses (10/20 µg) of recombinant HBV vaccine in months 0, 1, 6, were selected and tested for HBsAg, HBsAb and anti-HBc by ELISA method. Also, these sera were tested for HBV DNA using nested-PCR method. FINDINGS: In 99 beta-thalassemic children, 89 (89.9 %) were anti-HBs positive (responders) and 10 (10.1%) anti-HBs negative (non-responders). 3 (3.03%) were anti-HBc positive and 1(1.01%) was HBsAg positive. HBV DNA was not detected in any of them. CONCLUSION: Our results have revealed that hepatitis B vaccine is highly immunogenic for thalassemic children and particularly well tolerated. Tehran University of Medical Sciences 2010-06 /pmc/articles/PMC3446027/ /pubmed/23056706 Text en © 2010 Iranian Journal of Pediatrics & Tehran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. |
spellingShingle | Original Article Sharifi, Zohreh Milani, Saeideh Shooshtari, Mahmood Mahmoodian Study on Efficacy of Hepatitis B Immunization in Vaccinated Beta-thalassemia Children in Tehran |
title | Study on Efficacy of Hepatitis B Immunization in Vaccinated Beta-thalassemia Children in Tehran |
title_full | Study on Efficacy of Hepatitis B Immunization in Vaccinated Beta-thalassemia Children in Tehran |
title_fullStr | Study on Efficacy of Hepatitis B Immunization in Vaccinated Beta-thalassemia Children in Tehran |
title_full_unstemmed | Study on Efficacy of Hepatitis B Immunization in Vaccinated Beta-thalassemia Children in Tehran |
title_short | Study on Efficacy of Hepatitis B Immunization in Vaccinated Beta-thalassemia Children in Tehran |
title_sort | study on efficacy of hepatitis b immunization in vaccinated beta-thalassemia children in tehran |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446027/ https://www.ncbi.nlm.nih.gov/pubmed/23056706 |
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