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Study on Efficacy of Hepatitis B Immunization in Vaccinated Beta-thalassemia Children in Tehran

OBJECTIVE: In thalassemic children, HBV infection is common, thus immunization against HBV will reduce and prevent the rate of infection. The aim of this study was to evaluate the efficacy of HBV immunization and the prevalence of HBV infection in beta-thalassemic children in Tehran. METHODS: To ass...

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Autores principales: Sharifi, Zohreh, Milani, Saeideh, Shooshtari, Mahmood Mahmoodian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446027/
https://www.ncbi.nlm.nih.gov/pubmed/23056706
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author Sharifi, Zohreh
Milani, Saeideh
Shooshtari, Mahmood Mahmoodian
author_facet Sharifi, Zohreh
Milani, Saeideh
Shooshtari, Mahmood Mahmoodian
author_sort Sharifi, Zohreh
collection PubMed
description OBJECTIVE: In thalassemic children, HBV infection is common, thus immunization against HBV will reduce and prevent the rate of infection. The aim of this study was to evaluate the efficacy of HBV immunization and the prevalence of HBV infection in beta-thalassemic children in Tehran. METHODS: To assess the efficacy of immunization and determine the immune response of children with beta-thalassemia, sera of 99 children who had received three doses (10/20 µg) of recombinant HBV vaccine in months 0, 1, 6, were selected and tested for HBsAg, HBsAb and anti-HBc by ELISA method. Also, these sera were tested for HBV DNA using nested-PCR method. FINDINGS: In 99 beta-thalassemic children, 89 (89.9 %) were anti-HBs positive (responders) and 10 (10.1%) anti-HBs negative (non-responders). 3 (3.03%) were anti-HBc positive and 1(1.01%) was HBsAg positive. HBV DNA was not detected in any of them. CONCLUSION: Our results have revealed that hepatitis B vaccine is highly immunogenic for thalassemic children and particularly well tolerated.
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spelling pubmed-34460272012-10-09 Study on Efficacy of Hepatitis B Immunization in Vaccinated Beta-thalassemia Children in Tehran Sharifi, Zohreh Milani, Saeideh Shooshtari, Mahmood Mahmoodian Iran J Pediatr Original Article OBJECTIVE: In thalassemic children, HBV infection is common, thus immunization against HBV will reduce and prevent the rate of infection. The aim of this study was to evaluate the efficacy of HBV immunization and the prevalence of HBV infection in beta-thalassemic children in Tehran. METHODS: To assess the efficacy of immunization and determine the immune response of children with beta-thalassemia, sera of 99 children who had received three doses (10/20 µg) of recombinant HBV vaccine in months 0, 1, 6, were selected and tested for HBsAg, HBsAb and anti-HBc by ELISA method. Also, these sera were tested for HBV DNA using nested-PCR method. FINDINGS: In 99 beta-thalassemic children, 89 (89.9 %) were anti-HBs positive (responders) and 10 (10.1%) anti-HBs negative (non-responders). 3 (3.03%) were anti-HBc positive and 1(1.01%) was HBsAg positive. HBV DNA was not detected in any of them. CONCLUSION: Our results have revealed that hepatitis B vaccine is highly immunogenic for thalassemic children and particularly well tolerated. Tehran University of Medical Sciences 2010-06 /pmc/articles/PMC3446027/ /pubmed/23056706 Text en © 2010 Iranian Journal of Pediatrics & Tehran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Sharifi, Zohreh
Milani, Saeideh
Shooshtari, Mahmood Mahmoodian
Study on Efficacy of Hepatitis B Immunization in Vaccinated Beta-thalassemia Children in Tehran
title Study on Efficacy of Hepatitis B Immunization in Vaccinated Beta-thalassemia Children in Tehran
title_full Study on Efficacy of Hepatitis B Immunization in Vaccinated Beta-thalassemia Children in Tehran
title_fullStr Study on Efficacy of Hepatitis B Immunization in Vaccinated Beta-thalassemia Children in Tehran
title_full_unstemmed Study on Efficacy of Hepatitis B Immunization in Vaccinated Beta-thalassemia Children in Tehran
title_short Study on Efficacy of Hepatitis B Immunization in Vaccinated Beta-thalassemia Children in Tehran
title_sort study on efficacy of hepatitis b immunization in vaccinated beta-thalassemia children in tehran
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446027/
https://www.ncbi.nlm.nih.gov/pubmed/23056706
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