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Zinc and Copper Status in Children with Beta-Thalassemia Major
OBJECTIVE: There are some reports in which a condition of zinc deficiency and its associated outcomes with a change in concentration of serum copper among the thalassemic patients has been highlighted. The aim of this prospective study was to determine the serum zinc and copper levels in children wi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tehran University of Medical Sciences
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446035/ https://www.ncbi.nlm.nih.gov/pubmed/23056720 |
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author | Mahyar, Abolfazl Ayazi, Parviz Pahlevan, Ali-Asghar Mojabi, Hoshyar Sehhat, Mohammad-Reza Javadi, Amir |
author_facet | Mahyar, Abolfazl Ayazi, Parviz Pahlevan, Ali-Asghar Mojabi, Hoshyar Sehhat, Mohammad-Reza Javadi, Amir |
author_sort | Mahyar, Abolfazl |
collection | PubMed |
description | OBJECTIVE: There are some reports in which a condition of zinc deficiency and its associated outcomes with a change in concentration of serum copper among the thalassemic patients has been highlighted. The aim of this prospective study was to determine the serum zinc and copper levels in children with beta-thalassemia major. METHODS: In this cross sectional study all children under 12 years affected by beta thalassemia major (40 patients) were evaluated for serum zinc and copper levels in Qazvin thalassemia center (Qazvin, Iran) in 2007. Serum measurements for zinc and copper were performed by atomic absorption spectrophotometer. FINDINGS: The mean concentrations of serum zinc and copper levels were 67.35±20.38 and 152.42±24.17 µg/dl respectively. Twenty-six (65%) of thalassemic patients had zinc concentration under 70 µg/dl (hypozincemia). None of the thalassemic children had copper deficiency. No significant correlation between serum zinc level with age, weight, height, body mass index, duration of blood transfusion, desferrioxamine dose and ferritin level was observed in thalassemic patients (P=0.3). CONCLUSION: This study revealed that hypozincemia is common in thalassemic patients, but in contrast, there is no copper deficiency. Further evaluation in this regard is recommended. |
format | Online Article Text |
id | pubmed-3446035 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Tehran University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-34460352012-10-09 Zinc and Copper Status in Children with Beta-Thalassemia Major Mahyar, Abolfazl Ayazi, Parviz Pahlevan, Ali-Asghar Mojabi, Hoshyar Sehhat, Mohammad-Reza Javadi, Amir Iran J Pediatr Original Article OBJECTIVE: There are some reports in which a condition of zinc deficiency and its associated outcomes with a change in concentration of serum copper among the thalassemic patients has been highlighted. The aim of this prospective study was to determine the serum zinc and copper levels in children with beta-thalassemia major. METHODS: In this cross sectional study all children under 12 years affected by beta thalassemia major (40 patients) were evaluated for serum zinc and copper levels in Qazvin thalassemia center (Qazvin, Iran) in 2007. Serum measurements for zinc and copper were performed by atomic absorption spectrophotometer. FINDINGS: The mean concentrations of serum zinc and copper levels were 67.35±20.38 and 152.42±24.17 µg/dl respectively. Twenty-six (65%) of thalassemic patients had zinc concentration under 70 µg/dl (hypozincemia). None of the thalassemic children had copper deficiency. No significant correlation between serum zinc level with age, weight, height, body mass index, duration of blood transfusion, desferrioxamine dose and ferritin level was observed in thalassemic patients (P=0.3). CONCLUSION: This study revealed that hypozincemia is common in thalassemic patients, but in contrast, there is no copper deficiency. Further evaluation in this regard is recommended. Tehran University of Medical Sciences 2010-09 /pmc/articles/PMC3446035/ /pubmed/23056720 Text en © 2010 Iranian Journal of Pediatrics & Tehran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. |
spellingShingle | Original Article Mahyar, Abolfazl Ayazi, Parviz Pahlevan, Ali-Asghar Mojabi, Hoshyar Sehhat, Mohammad-Reza Javadi, Amir Zinc and Copper Status in Children with Beta-Thalassemia Major |
title | Zinc and Copper Status in Children with Beta-Thalassemia Major
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title_full | Zinc and Copper Status in Children with Beta-Thalassemia Major
|
title_fullStr | Zinc and Copper Status in Children with Beta-Thalassemia Major
|
title_full_unstemmed | Zinc and Copper Status in Children with Beta-Thalassemia Major
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title_short | Zinc and Copper Status in Children with Beta-Thalassemia Major
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title_sort | zinc and copper status in children with beta-thalassemia major |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446035/ https://www.ncbi.nlm.nih.gov/pubmed/23056720 |
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