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Effect of Anti-Epileptic Drugs on Serum Level of IgG Subclasses

OBJECTIVE: There are some controversial studies on effects of anti-epileptic drugs (AEDs) on serum IgG subclasses; however, the role of these medications is still unclear. The aim of this study was evaluation the effects of anti-epileptic drugs on serum concentration of IgG and its subclasses METHOD...

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Autores principales: Ashrafi, Mahmoud-Reza, Hosseini, Seyed-Ahmad, Biglari, Mohammad, Abolmaali, Sarah, Azizi Malamiri, Reza, Mombeini, Hoda, Pourpak, Zahra, Saladjegheh, Narges, Rezaei, Nima, Samadian, Azam, Aghamohammadi, Asghar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446037/
https://www.ncbi.nlm.nih.gov/pubmed/23056716
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author Ashrafi, Mahmoud-Reza
Hosseini, Seyed-Ahmad
Biglari, Mohammad
Abolmaali, Sarah
Azizi Malamiri, Reza
Mombeini, Hoda
Pourpak, Zahra
Saladjegheh, Narges
Rezaei, Nima
Samadian, Azam
Aghamohammadi, Asghar
author_facet Ashrafi, Mahmoud-Reza
Hosseini, Seyed-Ahmad
Biglari, Mohammad
Abolmaali, Sarah
Azizi Malamiri, Reza
Mombeini, Hoda
Pourpak, Zahra
Saladjegheh, Narges
Rezaei, Nima
Samadian, Azam
Aghamohammadi, Asghar
author_sort Ashrafi, Mahmoud-Reza
collection PubMed
description OBJECTIVE: There are some controversial studies on effects of anti-epileptic drugs (AEDs) on serum IgG subclasses; however, the role of these medications is still unclear. The aim of this study was evaluation the effects of anti-epileptic drugs on serum concentration of IgG and its subclasses METHODS: Serum IgG and IgG subclasses of 61 newly diagnosed epileptic patients were measured at the beginning of monotherapy with carbamazepine, sodium valproate, and phenobarbital, and 6 months later. Measurement of IgG and its subclasses was performed using nephlometry and ELISA techniques, respectively. FINDINGS: Reduction of at least one IgG subclass was found in 6 patients 6 months after treatment with AEDs. Among 27 patients receiving carbamazepine, decrease in at least one serum IgG subclass level was found in 5 patients. Among 20 patients using sodium valproate, only one patient showed decrease in IgG2 subclass. None of the 14 patients using phenobarbital revealed significant decrease in IgG subclasses. No infection was seen in the patients with reduction of subclasses. CONCLUSION: Although in our study, children with selective IgG subclass deficiency were asymptomatic, assessment of serum immunoglobulin levels could be recommended at starting the administration of AEDs and in serial intervals afterward in epileptic patients.
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spelling pubmed-34460372012-10-09 Effect of Anti-Epileptic Drugs on Serum Level of IgG Subclasses Ashrafi, Mahmoud-Reza Hosseini, Seyed-Ahmad Biglari, Mohammad Abolmaali, Sarah Azizi Malamiri, Reza Mombeini, Hoda Pourpak, Zahra Saladjegheh, Narges Rezaei, Nima Samadian, Azam Aghamohammadi, Asghar Iran J Pediatr Original Article OBJECTIVE: There are some controversial studies on effects of anti-epileptic drugs (AEDs) on serum IgG subclasses; however, the role of these medications is still unclear. The aim of this study was evaluation the effects of anti-epileptic drugs on serum concentration of IgG and its subclasses METHODS: Serum IgG and IgG subclasses of 61 newly diagnosed epileptic patients were measured at the beginning of monotherapy with carbamazepine, sodium valproate, and phenobarbital, and 6 months later. Measurement of IgG and its subclasses was performed using nephlometry and ELISA techniques, respectively. FINDINGS: Reduction of at least one IgG subclass was found in 6 patients 6 months after treatment with AEDs. Among 27 patients receiving carbamazepine, decrease in at least one serum IgG subclass level was found in 5 patients. Among 20 patients using sodium valproate, only one patient showed decrease in IgG2 subclass. None of the 14 patients using phenobarbital revealed significant decrease in IgG subclasses. No infection was seen in the patients with reduction of subclasses. CONCLUSION: Although in our study, children with selective IgG subclass deficiency were asymptomatic, assessment of serum immunoglobulin levels could be recommended at starting the administration of AEDs and in serial intervals afterward in epileptic patients. Tehran University of Medical Sciences 2010-09 /pmc/articles/PMC3446037/ /pubmed/23056716 Text en © 2010 Iranian Journal of Pediatrics & Tehran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Ashrafi, Mahmoud-Reza
Hosseini, Seyed-Ahmad
Biglari, Mohammad
Abolmaali, Sarah
Azizi Malamiri, Reza
Mombeini, Hoda
Pourpak, Zahra
Saladjegheh, Narges
Rezaei, Nima
Samadian, Azam
Aghamohammadi, Asghar
Effect of Anti-Epileptic Drugs on Serum Level of IgG Subclasses
title Effect of Anti-Epileptic Drugs on Serum Level of IgG Subclasses
title_full Effect of Anti-Epileptic Drugs on Serum Level of IgG Subclasses
title_fullStr Effect of Anti-Epileptic Drugs on Serum Level of IgG Subclasses
title_full_unstemmed Effect of Anti-Epileptic Drugs on Serum Level of IgG Subclasses
title_short Effect of Anti-Epileptic Drugs on Serum Level of IgG Subclasses
title_sort effect of anti-epileptic drugs on serum level of igg subclasses
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446037/
https://www.ncbi.nlm.nih.gov/pubmed/23056716
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