Successful Treatment of Fungal Osteomyelitis with Voriconazole in a Patient with Chronic Granulomatous Disease

BACKGROUND: Chronic granulomatous disease (CGD) is an immunodeficiency affecting phagocytic leukocytes. Defective respiratory burst mechanism renders the affected patients to be susceptible to catalase positive microorganisms. With the great successes in antibacterial prophylaxis and therapy, fungal...

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Autores principales: Mohammadpour, Masoud, Mamishi, Setareh, Oaji, Mahsa, Pourpak, Zahra, Parvaneh, Nima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2010
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446094/
https://www.ncbi.nlm.nih.gov/pubmed/23056752
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author Mohammadpour, Masoud
Mamishi, Setareh
Oaji, Mahsa
Pourpak, Zahra
Parvaneh, Nima
author_facet Mohammadpour, Masoud
Mamishi, Setareh
Oaji, Mahsa
Pourpak, Zahra
Parvaneh, Nima
author_sort Mohammadpour, Masoud
collection PubMed
description BACKGROUND: Chronic granulomatous disease (CGD) is an immunodeficiency affecting phagocytic leukocytes. Defective respiratory burst mechanism renders the affected patients to be susceptible to catalase positive microorganisms. With the great successes in antibacterial prophylaxis and therapy, fungal infections are a persistent problem. Invasive aspergillosis is the most important cause of mortality in CGD. CASE PRESENTATION: We describe a nine year-old boy with CGD who presented with aspergillus induced skull osteomyelitis. He was successfully treated with voriconazole after initial failure of amphotericin B therapy. CONCLUSION: Currently, newer triazoles are recommended as initial therapy for invasive aspergillosis in immunodeficiency states such as CGD.
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spelling pubmed-34460942012-10-09 Successful Treatment of Fungal Osteomyelitis with Voriconazole in a Patient with Chronic Granulomatous Disease Mohammadpour, Masoud Mamishi, Setareh Oaji, Mahsa Pourpak, Zahra Parvaneh, Nima Iran J Pediatr Case Report BACKGROUND: Chronic granulomatous disease (CGD) is an immunodeficiency affecting phagocytic leukocytes. Defective respiratory burst mechanism renders the affected patients to be susceptible to catalase positive microorganisms. With the great successes in antibacterial prophylaxis and therapy, fungal infections are a persistent problem. Invasive aspergillosis is the most important cause of mortality in CGD. CASE PRESENTATION: We describe a nine year-old boy with CGD who presented with aspergillus induced skull osteomyelitis. He was successfully treated with voriconazole after initial failure of amphotericin B therapy. CONCLUSION: Currently, newer triazoles are recommended as initial therapy for invasive aspergillosis in immunodeficiency states such as CGD. Tehran University of Medical Sciences 2010-12 /pmc/articles/PMC3446094/ /pubmed/23056752 Text en © 2010 Iranian Journal of Pediatrics & Tehran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Case Report
Mohammadpour, Masoud
Mamishi, Setareh
Oaji, Mahsa
Pourpak, Zahra
Parvaneh, Nima
Successful Treatment of Fungal Osteomyelitis with Voriconazole in a Patient with Chronic Granulomatous Disease
title Successful Treatment of Fungal Osteomyelitis with Voriconazole in a Patient with Chronic Granulomatous Disease
title_full Successful Treatment of Fungal Osteomyelitis with Voriconazole in a Patient with Chronic Granulomatous Disease
title_fullStr Successful Treatment of Fungal Osteomyelitis with Voriconazole in a Patient with Chronic Granulomatous Disease
title_full_unstemmed Successful Treatment of Fungal Osteomyelitis with Voriconazole in a Patient with Chronic Granulomatous Disease
title_short Successful Treatment of Fungal Osteomyelitis with Voriconazole in a Patient with Chronic Granulomatous Disease
title_sort successful treatment of fungal osteomyelitis with voriconazole in a patient with chronic granulomatous disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446094/
https://www.ncbi.nlm.nih.gov/pubmed/23056752
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