Genetic architecture of body size in mammals

Much of the heritability for human stature is caused by mutations of small-to-medium effect. This is because detrimental pleiotropy restricts large-effect mutations to very low frequencies.

Detalles Bibliográficos
Autores principales: Kemper, Kathryn E, Visscher, Peter M, Goddard, Michael E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446298/
https://www.ncbi.nlm.nih.gov/pubmed/22546202
http://dx.doi.org/10.1186/gb-2012-13-4-244
Descripción
Sumario:Much of the heritability for human stature is caused by mutations of small-to-medium effect. This is because detrimental pleiotropy restricts large-effect mutations to very low frequencies.

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