Highly interconnected genes in disease-specific networks are enriched for disease-associated polymorphisms

BACKGROUND: Complex diseases are associated with altered interactions between thousands of genes. We developed a novel method to identify and prioritize disease genes, which was generally applicable to complex diseases. RESULTS: We identified modules of highly interconnected genes in disease-specifi...

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Detalles Bibliográficos
Autores principales: Barrenäs, Fredrik, Chavali, Sreenivas, Alves, Alexessander Couto, Coin, Lachlan, Jarvelin, Marjo-Riitta, Jörnsten, Rebecka, Langston, Michael A, Ramasamy, Adaikalavan, Rogers, Gary, Wang, Hui, Benson, Mikael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446318/
https://www.ncbi.nlm.nih.gov/pubmed/22703998
http://dx.doi.org/10.1186/gb-2012-13-6-r46

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