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Challenges and opportunities in the targeting of fibroblast growth factor receptors in breast cancer

Activation of the fibroblast growth factor receptor pathway is a common event in many cancer types. Here we review the role of fibroblast growth factor receptor signalling in breast cancer, from SNPs in FGFR2 that influence breast cancer risk and SNPs in FGFR4 that associate with breast cancer progn...

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Detalles Bibliográficos
Autores principales: Jain, Vikram K, Turner, Nicholas C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446326/
https://www.ncbi.nlm.nih.gov/pubmed/22731805
http://dx.doi.org/10.1186/bcr3139
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author Jain, Vikram K
Turner, Nicholas C
author_facet Jain, Vikram K
Turner, Nicholas C
author_sort Jain, Vikram K
collection PubMed
description Activation of the fibroblast growth factor receptor pathway is a common event in many cancer types. Here we review the role of fibroblast growth factor receptor signalling in breast cancer, from SNPs in FGFR2 that influence breast cancer risk and SNPs in FGFR4 that associate with breast cancer prognosis, and potential therapeutic targets such as receptor amplification and aberrant autocrine and paracrine ligand expression. We discuss the multiple therapeutic strategies in preclinical and clinical development and the current and future challenges to successfully targeting this pathway in cancer.
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spelling pubmed-34463262012-12-19 Challenges and opportunities in the targeting of fibroblast growth factor receptors in breast cancer Jain, Vikram K Turner, Nicholas C Breast Cancer Res Review Activation of the fibroblast growth factor receptor pathway is a common event in many cancer types. Here we review the role of fibroblast growth factor receptor signalling in breast cancer, from SNPs in FGFR2 that influence breast cancer risk and SNPs in FGFR4 that associate with breast cancer prognosis, and potential therapeutic targets such as receptor amplification and aberrant autocrine and paracrine ligand expression. We discuss the multiple therapeutic strategies in preclinical and clinical development and the current and future challenges to successfully targeting this pathway in cancer. BioMed Central 2012 2012-06-19 /pmc/articles/PMC3446326/ /pubmed/22731805 http://dx.doi.org/10.1186/bcr3139 Text en Copyright ©2012 BioMed Central Ltd
spellingShingle Review
Jain, Vikram K
Turner, Nicholas C
Challenges and opportunities in the targeting of fibroblast growth factor receptors in breast cancer
title Challenges and opportunities in the targeting of fibroblast growth factor receptors in breast cancer
title_full Challenges and opportunities in the targeting of fibroblast growth factor receptors in breast cancer
title_fullStr Challenges and opportunities in the targeting of fibroblast growth factor receptors in breast cancer
title_full_unstemmed Challenges and opportunities in the targeting of fibroblast growth factor receptors in breast cancer
title_short Challenges and opportunities in the targeting of fibroblast growth factor receptors in breast cancer
title_sort challenges and opportunities in the targeting of fibroblast growth factor receptors in breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446326/
https://www.ncbi.nlm.nih.gov/pubmed/22731805
http://dx.doi.org/10.1186/bcr3139
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