Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells

INTRODUCTION: Sustained HER2 signaling at the cell surface is an oncogenic mechanism in a significant proportion of breast cancers. While clinically effective therapies targeting HER2 such as mAbs and tyrosine kinase inhibitors exist, tumors overexpressing HER2 eventually progress despite treatment....

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Detalles Bibliográficos
Autores principales: Ren, Xiu-Rong, Wei, Junping, Lei, Gangjun, Wang, Jiangbo, Lu, Jiuyi, Xia, Wenle, Spector, Neil, Barak, Larry S, Clay, Timothy M, Osada, Takuya, Hamilton, Erika, Blackwell, Kimberly, Hobeika, Amy C, Morse, Michael A, Lyerly, H Kim, Chen, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446352/
https://www.ncbi.nlm.nih.gov/pubmed/22676470
http://dx.doi.org/10.1186/bcr3204

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