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Immunohistochemical detection of Polo-like kinase-1 (PLK1) in primary breast cancer is associated with TP53 mutation and poor clinical outcome

INTRODUCTION: Polo-like kinase-1 (PLK1) is a crucial driver of cell cycle progression and its down-regulation plays an important checkpoint role in response to DNA damage. Mechanistically, this is mediated by p53 which represses PLK1 expression through chromatin remodelling. Consistent with this mod...

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Detalles Bibliográficos
Autores principales:	King, Sharon I, Purdie, Colin A, Bray, Susan E, Quinlan, Philip R, Jordan, Lee B, Thompson, Alastair M, Meek, David W
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446374/ https://www.ncbi.nlm.nih.gov/pubmed/22405092 http://dx.doi.org/10.1186/bcr3136

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