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RAC1 GTPase plays an important role in γ-irradiation induced G(2)/M checkpoint activation

INTRODUCTION: In response to gamma-irradiation (IR)-induced double-strand DNA breaks, cells undergo cell-cycle arrest, allowing time for DNA repair before reentering the cell cycle. G(2)/M checkpoint activation involves activation of ataxia telangiectasia mutated (ATM)/ATM- and rad3-related (ATR) ki...

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Detalles Bibliográficos
Autores principales:	Yan, Ying, Greer, Patrick M, Cao, Phu T, Kolb, Ryan H, Cowan, Kenneth H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446395/ https://www.ncbi.nlm.nih.gov/pubmed/22494620 http://dx.doi.org/10.1186/bcr3164

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