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Enhanced RAD21 cohesin expression confers poor prognosis in BRCA2 and BRCAX, but not BRCA1 familial breast cancers

INTRODUCTION: The RAD21 gene encodes a key component of the cohesin complex, which is essential for chromosome segregation, and together with BRCA1 and BRCA2, for high-fidelity DNA repair by homologous recombination. Although its expression correlates with early relapse and treatment resistance in s...

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Detalles Bibliográficos
Autores principales:	Yan, Max, Xu, Huiling, Waddell, Nic, Shield-Artin, Kristy, Haviv, Izhak, McKay, Michael J, Fox, Stephen B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446404/ https://www.ncbi.nlm.nih.gov/pubmed/22537934 http://dx.doi.org/10.1186/bcr3176

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