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Plasma proteins take their toll on the joint in osteoarthritis

In their recent study, Sohn and colleagues identify multiple plasma proteins in the synovial fluid of patients with osteoarthritis (OA) and demonstrate the capacity of several of the proteins to activate macrophages via the innate immune receptor Toll-like receptor-4 (TLR-4). The authors speculate t...

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Detalles Bibliográficos
Autores principales: Goldring, Steven R, Scanzello, Carla R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446406/
https://www.ncbi.nlm.nih.gov/pubmed/22385929
http://dx.doi.org/10.1186/ar3741
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author Goldring, Steven R
Scanzello, Carla R
author_facet Goldring, Steven R
Scanzello, Carla R
author_sort Goldring, Steven R
collection PubMed
description In their recent study, Sohn and colleagues identify multiple plasma proteins in the synovial fluid of patients with osteoarthritis (OA) and demonstrate the capacity of several of the proteins to activate macrophages via the innate immune receptor Toll-like receptor-4 (TLR-4). The authors speculate that the plasma proteins transit into the synovial compartment at sites of tissue damage where the endothelial barrier may be compromised, thus bringing them into contact with the articular surface and cells within the synovium. These results demonstrate a novel mechanism by which synovial inflammation can be initiated in patients with OA and how this process may contribute to the pathogenesis of OA joint pathology.
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spelling pubmed-34464062012-09-20 Plasma proteins take their toll on the joint in osteoarthritis Goldring, Steven R Scanzello, Carla R Arthritis Res Ther Editorial In their recent study, Sohn and colleagues identify multiple plasma proteins in the synovial fluid of patients with osteoarthritis (OA) and demonstrate the capacity of several of the proteins to activate macrophages via the innate immune receptor Toll-like receptor-4 (TLR-4). The authors speculate that the plasma proteins transit into the synovial compartment at sites of tissue damage where the endothelial barrier may be compromised, thus bringing them into contact with the articular surface and cells within the synovium. These results demonstrate a novel mechanism by which synovial inflammation can be initiated in patients with OA and how this process may contribute to the pathogenesis of OA joint pathology. BioMed Central 2012 2012-03-05 /pmc/articles/PMC3446406/ /pubmed/22385929 http://dx.doi.org/10.1186/ar3741 Text en Copyright ©2012 BioMed Central Ltd
spellingShingle Editorial
Goldring, Steven R
Scanzello, Carla R
Plasma proteins take their toll on the joint in osteoarthritis
title Plasma proteins take their toll on the joint in osteoarthritis
title_full Plasma proteins take their toll on the joint in osteoarthritis
title_fullStr Plasma proteins take their toll on the joint in osteoarthritis
title_full_unstemmed Plasma proteins take their toll on the joint in osteoarthritis
title_short Plasma proteins take their toll on the joint in osteoarthritis
title_sort plasma proteins take their toll on the joint in osteoarthritis
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446406/
https://www.ncbi.nlm.nih.gov/pubmed/22385929
http://dx.doi.org/10.1186/ar3741
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