Cargando…

Altered responsiveness to TGF-β results in reduced Papss2 expression and alterations in the biomechanical properties of mouse articular cartilage

INTRODUCTION: Previous studies have indicated that transforming growth factor β (TGF-β) signaling has a critical role in cartilage homeostasis and repair, yet the mechanisms of TGF-β's chondroprotective effects are not known. Our objective in this study was to identify downstream targets of TGF...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ramaswamy, Girish, Sohn, Philip, Eberhardt, Alan, Serra, Rosa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446415/ https://www.ncbi.nlm.nih.gov/pubmed/22394585 http://dx.doi.org/10.1186/ar3762

Ejemplares similares

Depletion of chondrocyte primary cilia reduces the compressive modulus of articular cartilage()
por: Irianto, Jerome, et al.
Publicado: (2014)

Osteoarthritis-Related Degeneration Alters the Biomechanical Properties of Human Menisci Before the Articular Cartilage
por: Seitz, Andreas M., et al.
Publicado: (2021)

Intra-articular injection of epigallocatechin (EGCG) crosslinks and alters biomechanical properties of articular cartilage, a study via nanoindentation
por: Reiter, Mary Pat, et al.
Publicado: (2022)

Mechanical stress determines the configuration of TGFβ activation in articular cartilage
por: Zhen, Gehua, et al.
Publicado: (2021)

The Influence of Articular Cartilage Thickness Reduction on Meniscus Biomechanics
por: Łuczkiewicz, Piotr, et al.
Publicado: (2016)

PAPSS2 Deficiency Causes Androgen Excess via Impaired DHEA Sulfation—In Vitro and in Vivo Studies in a Family Harboring Two Novel PAPSS2 Mutations
por: Oostdijk, Wilma, et al.
Publicado: (2015)

Runx1 is a key regulator of articular cartilage homeostasis by orchestrating YAP, TGFβ, and Wnt signaling in articular cartilage formation and osteoarthritis
por: Zhang, Yan, et al.
Publicado: (2022)

Physicochemical and Biomechanical Stimuli in Cell-Based Articular Cartilage Repair
por: Jahr, Holger, et al.
Publicado: (2015)

A novel construct with biomechanical flexibility for articular cartilage regeneration
por: Cheng, Baixiang, et al.
Publicado: (2019)

An ultrasound study of altered hydration behaviour of proteoglycan-degraded articular cartilage
por: Wang, Qing, et al.
Publicado: (2013)

An altered heparan sulfate structure in the articular cartilage protects against osteoarthritis
por: Severmann, A.-C., et al.
Publicado: (2020)

Novel Inactivating Homozygous PAPSS2 Mutation in Two Siblings With Disproportionate Short Stature
por: Perez-Garcia, E. Melissa, et al.
Publicado: (2021)

Rapid CT-based Estimation of Articular Cartilage Biomechanics in the Knee Joint Without Cartilage Segmentation
por: Mohammadi, Ali, et al.
Publicado: (2020)

Biomechanical, Morphological, and Biochemical Characteristics of Articular Cartilage of the Ovine Humeral Head
por: McCready, Erin, et al.
Publicado: (2022)

TGF-β/Smad3 Signals Repress Chondrocyte Hypertrophic Differentiation and Are Required for Maintaining Articular Cartilage
por: Yang, Xiao, et al.
Publicado: (2001)

rAAV-mediated overexpression of TGF-β stably restructures human osteoarthritic articular cartilage in situ
por: Venkatesan, Jagadeesh K, et al.
Publicado: (2013)

Cbfβ Is a Novel Modulator against Osteoarthritis by Maintaining Articular Cartilage Homeostasis through TGF-β Signaling
por: Che, Xiangguo, et al.
Publicado: (2023)

Articular cartilage and changes in Arthritis: Collagen of articular cartilage
por: Eyre, David
Publicado: (2002)

Bushenhuoxue Formula Facilitates Articular Cartilage Repair and Attenuates Matrix Degradation by Activation of TGF-β Signaling Pathway
por: Dong, Rui, et al.
Publicado: (2018)

Parathyroid Hormone–related Peptide (PTHrP)-dependent and -independent Effects of Transforming Growth Factor β (TGF-β) on Endochondral Bone Formation
por: Serra, Rosa, et al.
Publicado: (1999)

A Biomechanical and Structural Comparison of Articular Cartilage and Subchondral Bone of the Glenoid and Humeral Head
por: Loy, Bo Nasmyth, et al.
Publicado: (2018)

Composition, structure and tensile biomechanical properties of equine articular cartilage during growth and maturation
por: Oinas, J., et al.
Publicado: (2018)

Disease-Related Protein Variants of the Highly Conserved Enzyme PAPSS2 Show Marginal Stability and Aggregation in Cells
por: Brylski, Oliver, et al.
Publicado: (2022)

Morphological and mechanical alterations in articular cartilage and subchondral bone during spontaneous hip osteoarthritis in guinea pigs
por: Gao, Jiazi, et al.
Publicado: (2023)

Age-dependent alteration of TGF-β signalling in osteoarthritis
por: van der Kraan, Peter M., et al.
Publicado: (2011)

Aggrecan Hypomorphism Compromises Articular Cartilage Biomechanical Properties and Is Associated with Increased Incidence of Spontaneous Osteoarthritis
por: Alberton, Paolo, et al.
Publicado: (2019)

The Importance of Controlled Mismatch of Biomechanical Compliances of Implantable Scaffolds and Native Tissue for Articular Cartilage Regeneration
por: Gasik, Michael, et al.
Publicado: (2018)

An original method of simulating the articular cartilage in the context of in vitro biomechanical studies investigating the proximal femur
por: Gheorghevici, Teodor Stefan, et al.
Publicado: (2022)

An in vitro investigation to understand the synergistic role of MMPs-1 and 9 on articular cartilage biomechanical properties
por: Mixon, Allison, et al.
Publicado: (2021)

Plasmin and Articular Cartilage
por: Chrisman, O. Donald, et al.
Publicado: (1962)

Adult articular cartilage
por: Freeman, Michael Alexander Reykers, 1931-
Publicado: (1974)

Imaging of articular cartilage
por: Paunipagar, Bhawan K, et al.
Publicado: (2014)

Equine Models of Articular Cartilage Repair
por: McIlwraith, C. Wayne, et al.
Publicado: (2011)

The osteoarthritis-associated gene PAPSS2 promotes differentiation and matrix formation in ATDC5 chondrogenic cells
por: Fan, Liying, et al.
Publicado: (2018)

Identification of variants in ACAN and PAPSS2 leading to spondyloepi(meta)physeal dysplasias in four Chinese families
por: Cao, Yixuan, et al.
Publicado: (2022)

Priming Adipose-Derived Mesenchymal Stem Cells with Hyaluronan Alters Growth Kinetics and Increases Attachment to Articular Cartilage
por: Succar, Peter, et al.
Publicado: (2016)

Morphological and Microstructural Alterations of the Articular Cartilage and Bones during Treadmill Exercises with Different Additional Weight-Bearing Levels
por: Gao, Jiazi, et al.
Publicado: (2017)

Age-related alterations of articular cartilage in pituitary adenylate cyclase–activating polypeptide (PACAP) gene–deficient mice
por: Szegeczki, Vince, et al.
Publicado: (2019)

Silk fibroin hydrogel scaffolds incorporated with chitosan nanoparticles repair articular cartilage defects by regulating TGF-β1 and BMP-2
por: Li, Yuan, et al.
Publicado: (2021)

Effects of Freeze–Thaw Cycle with and without Proteolysis Inhibitors and Cryopreservant on the Biochemical and Biomechanical Properties of Articular Cartilage
por: Qu, Chengjuan, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_ku3emala39tsehm0r2bjcpvoif