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Induction of long-term B-cell depletion in refractory rheumatoid arthritis patients preferentially affects autoreactive more than protective humoral immunity

INTRODUCTION: B-cell depletion has become a common treatment strategy in anti-TNF-refractory rheumatoid arthritis (RA). Although the exact mechanism of how B-cell depletion leads to clinical amelioration in RA remains to be elucidated, repetitive treatment with B-cell-depleting agents leading to lon...

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Detalles Bibliográficos
Autores principales:	Teng, YK Onno, Wheater, Gillian, Hogan, Vanessa E, Stocks, Philip, Levarht, EW Nivine, Huizinga, Tom WJ, Toes, Rene EM, van Laar, Jacob M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446423/ https://www.ncbi.nlm.nih.gov/pubmed/22409963 http://dx.doi.org/10.1186/ar3770

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