Cargando…

Induction of long-term B-cell depletion in refractory rheumatoid arthritis patients preferentially affects autoreactive more than protective humoral immunity

INTRODUCTION: B-cell depletion has become a common treatment strategy in anti-TNF-refractory rheumatoid arthritis (RA). Although the exact mechanism of how B-cell depletion leads to clinical amelioration in RA remains to be elucidated, repetitive treatment with B-cell-depleting agents leading to lon...

Descripción completa

Detalles Bibliográficos
Autores principales:	Teng, YK Onno, Wheater, Gillian, Hogan, Vanessa E, Stocks, Philip, Levarht, EW Nivine, Huizinga, Tom WJ, Toes, Rene EM, van Laar, Jacob M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446423/ https://www.ncbi.nlm.nih.gov/pubmed/22409963 http://dx.doi.org/10.1186/ar3770

Ejemplares similares

Anti-citrullinated protein antibodies contribute to platelet activation in rheumatoid arthritis
por: Habets, Kim L.L., et al.
Publicado: (2015)

Differential responsiveness to immunoablative therapy in refractory rheumatoid arthritis is associated with level and avidity of anti-cyclic citrullinated protein autoantibodies: a case study
por: Teng, YK Onno, et al.
Publicado: (2007)

The fine specificity of IgM anti-citrullinated protein antibodies (ACPA) is different from that of IgG ACPA
por: Suwannalai, Parawee, et al.
Publicado: (2011)

The specificity of anti-carbamylated protein antibodies for rheumatoid arthritis in a setting of early arthritis
por: Shi, Jing, et al.
Publicado: (2015)

Autoreactive B cells in rheumatoid arthritis include mainly activated CXCR3(+) memory B cells and plasmablasts
por: Reijm, Sanne, et al.
Publicado: (2023)

Rheumatoid arthritis – class prediction by autoreactivity profiles
por: Bergholz, R, et al.
Publicado: (2003)

Changes in bone density and bone turnover in patients with rheumatoid arthritis treated with rituximab, a B cell depleting monoclonal antibody (HORUS TRIAL)
por: Elshahaly, Mohsen, et al.
Publicado: (2013)

Integration of gene ontology pathways with North American Rheumatoid Arthritis Consortium genome-wide association data via linear modeling
por: Lebrec, Jérémie JP, et al.
Publicado: (2009)

Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis
por: van der Helm-van Mil, Annette HM, et al.
Publicado: (2005)

Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25(+) Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses
por: Sutmuller, Roger P.M., et al.
Publicado: (2001)

Anti-carbamylated protein antibodies in systemic sclerosis
por: Liem, Sophie I. E., et al.
Publicado: (2023)

Autoreactivity patterns in rheumatoid arthritis
por: Behrens, S, et al.
Publicado: (2001)

High-dose chemotherapy and syngeneic stem cell transplantation in a patient with refractory rheumatoid arthritis: poor response associated with persistence of synovial abnormalities
por: van Oosterhout, M, et al.
Publicado: (2005)

Mast cells are the main interleukin 17-positive cells in anticitrullinated protein antibody-positive and -negative rheumatoid arthritis and osteoarthritis synovium
por: Suurmond, Jolien, et al.
Publicado: (2011)

Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation
por: Kissel, Theresa, et al.
Publicado: (2022)

Bone marker reference range study: a comparison of the manufacturer’s reference range and laboratory healthy volunteer results to patients with rheumatoid arthritis
por: Wheater, Gillian, et al.
Publicado: (2013)

Sequential Prodrug Strategy To Target and Eliminate ACPA-Selective Autoreactive B Cells
por: Lelieveldt, Lianne P. W. M., et al.
Publicado: (2018)

Induction of autoreactive B cells allows priming of autoreactive T cells
Publicado: (1991)

Autoimmune Responses in the Rheumatoid Synovium
por: Toes, Rene E. M, et al.
Publicado: (2009)

Cross-reactivity of IgM anti-modified protein antibodies in rheumatoid arthritis despite limited mutational load
por: Reijm, Sanne, et al.
Publicado: (2021)

Genetic correlates of autoreactivity and autoreactive potential in human Ig heavy chains
por: Volpe, Joseph M, et al.
Publicado: (2009)

Changes in bone density and bone turnover in patients with rheumatoid arthritis treated with rituximab, results from an exploratory, prospective study
por: Wheater, Gillian, et al.
Publicado: (2018)

Multifunctional, Multivalent PIC Polymer Scaffolds for Targeting Antigen-Specific, Autoreactive B Cells
por: Kristyanto, Hendy, et al.
Publicado: (2022)

Primary HIV-1 Infection Is Associated with Preferential Depletion of CD4(+) T Lymphocytes from Effector Sites in the Gastrointestinal Tract
por: Mehandru, Saurabh, et al.
Publicado: (2004)

TRAF1/C5 polymorphism is not associated with increased mortality in rheumatoid arthritis: two large longitudinal studies
por: van Nies, Jessica AB, et al.
Publicado: (2010)

Autoantibodies predict progression to rheumatoid arthritis in undifferentiated arthritis: a prospective cohort study
por: van Gaalen, FA, et al.
Publicado: (2003)

B Cell Depletion Reduces the Number of Autoreactive T Helper Cells and Prevents Glucose-6-Phosphate Isomerase-Induced Arthritis
por: Frey, Oliver, et al.
Publicado: (2011)

"Rheumatoid Arthritis": A balanced overview of current research
por: Huizinga, Thomas WJ
Publicado: (2001)

Abatacept decreases disease activity in a absence of CD4(+) T cells in a collagen-induced arthritis model
por: Jansen, Diahann TSL, et al.
Publicado: (2015)

The secret autoreactivity of B cells
por: Williams, Ruth
Publicado: (2007)

The broad spectrum of pathogenic autoreactivity
por: Santambrogio, Laura, et al.
Publicado: (2022)

Response to “Tailored Use of Avacopan in a Case With Refractory Antineutrophil Cytoplasmic Autoantibody-Associated Renal Vasculitis and Concominant Complement System Activation”
por: van Leeuwen, Jolijn R., et al.
Publicado: (2022)

Targeted therapies in rheumatoid arthritis: Focus on rituximab
por: Teng, YKO, et al.
Publicado: (2007)

In vitro autoreactivity against autologous keratinocytes in patients with rheumatoid and juvenile idiopathic arthritis
por: Štechová, K, et al.
Publicado: (2001)

The clinical utility of bone marker measurements in osteoporosis
por: Wheater, Gillian, et al.
Publicado: (2013)

NK Cell Autoreactivity and Autoimmune Diseases
por: Poggi, Alessandro, et al.
Publicado: (2014)

Autoreactive T-Lymphocytes in Inflammatory Skin Diseases
por: Boehncke, Wolf-Henning, et al.
Publicado: (2019)

HLA class II and rheumatoid arthritis: the bumpy road of revelation
por: Kampstra, Arieke S.B., et al.
Publicado: (2017)

Transition of healthy to diseased synovial tissue in rheumatoid arthritis is associated with gain of mesenchymal/fibrotic characteristics
por: Steenvoorden, Marjan MC, et al.
Publicado: (2006)

Genetics of rheumatoid arthritis: what have we learned?
por: Bax, Marieke, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_tot9vbsqa9okt8mo1a99u5sr75