Cargando…

Role of non-immune mechanisms of muscle damage in idiopathic inflammatory myopathies

Idiopathic inflammatory myopathies (IIMs) comprise a group of autoimmune diseases that are characterized by symmetrical skeletal muscle weakness and muscle inflammation with no known cause. Like other autoimmune diseases, IIMs are treated with either glucocorticoids or immunosuppressive drugs. Howev...

Descripción completa

Detalles Bibliográficos
Autores principales: Coley, William, Rayavarapu, Sree, Nagaraju, Kanneboyina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446443/
https://www.ncbi.nlm.nih.gov/pubmed/22546362
http://dx.doi.org/10.1186/ar3791
_version_ 1782243976320909312
author Coley, William
Rayavarapu, Sree
Nagaraju, Kanneboyina
author_facet Coley, William
Rayavarapu, Sree
Nagaraju, Kanneboyina
author_sort Coley, William
collection PubMed
description Idiopathic inflammatory myopathies (IIMs) comprise a group of autoimmune diseases that are characterized by symmetrical skeletal muscle weakness and muscle inflammation with no known cause. Like other autoimmune diseases, IIMs are treated with either glucocorticoids or immunosuppressive drugs. However, many patients with an IIM are frequently resistant to immunosuppressive treatments, and there is compelling evidence to indicate that not only adaptive immune but also several non-immune mechanisms play a role in the pathogenesis of these disorders. Here, we focus on some of the evidence related to pathologic mechanisms, such as the innate immune response, endoplasmic reticulum stress, non-immune consequences of MHC class I overexpression, metabolic disturbances, and hypoxia. These mechanisms may explain how IIM-related pathologic processes can continue even in the face of immunosuppressive therapies. These data indicate that therapeutic strategies in IIMs should be directed at both immune and non-immune mechanisms of muscle damage.
format Online
Article
Text
id pubmed-3446443
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-34464432012-10-27 Role of non-immune mechanisms of muscle damage in idiopathic inflammatory myopathies Coley, William Rayavarapu, Sree Nagaraju, Kanneboyina Arthritis Res Ther Review Idiopathic inflammatory myopathies (IIMs) comprise a group of autoimmune diseases that are characterized by symmetrical skeletal muscle weakness and muscle inflammation with no known cause. Like other autoimmune diseases, IIMs are treated with either glucocorticoids or immunosuppressive drugs. However, many patients with an IIM are frequently resistant to immunosuppressive treatments, and there is compelling evidence to indicate that not only adaptive immune but also several non-immune mechanisms play a role in the pathogenesis of these disorders. Here, we focus on some of the evidence related to pathologic mechanisms, such as the innate immune response, endoplasmic reticulum stress, non-immune consequences of MHC class I overexpression, metabolic disturbances, and hypoxia. These mechanisms may explain how IIM-related pathologic processes can continue even in the face of immunosuppressive therapies. These data indicate that therapeutic strategies in IIMs should be directed at both immune and non-immune mechanisms of muscle damage. BioMed Central 2012 2012-04-27 /pmc/articles/PMC3446443/ /pubmed/22546362 http://dx.doi.org/10.1186/ar3791 Text en Copyright ©2012 BioMed Central Ltd
spellingShingle Review
Coley, William
Rayavarapu, Sree
Nagaraju, Kanneboyina
Role of non-immune mechanisms of muscle damage in idiopathic inflammatory myopathies
title Role of non-immune mechanisms of muscle damage in idiopathic inflammatory myopathies
title_full Role of non-immune mechanisms of muscle damage in idiopathic inflammatory myopathies
title_fullStr Role of non-immune mechanisms of muscle damage in idiopathic inflammatory myopathies
title_full_unstemmed Role of non-immune mechanisms of muscle damage in idiopathic inflammatory myopathies
title_short Role of non-immune mechanisms of muscle damage in idiopathic inflammatory myopathies
title_sort role of non-immune mechanisms of muscle damage in idiopathic inflammatory myopathies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446443/
https://www.ncbi.nlm.nih.gov/pubmed/22546362
http://dx.doi.org/10.1186/ar3791
work_keys_str_mv AT coleywilliam roleofnonimmunemechanismsofmuscledamageinidiopathicinflammatorymyopathies
AT rayavarapusree roleofnonimmunemechanismsofmuscledamageinidiopathicinflammatorymyopathies
AT nagarajukanneboyina roleofnonimmunemechanismsofmuscledamageinidiopathicinflammatorymyopathies