Cargando…

miR-146a, an IL-1β responsive miRNA, induces vascular endothelial growth factor and chondrocyte apoptosis by targeting Smad4

INTRODUCTION: miR-146a is one of the first identified miRNAs expressed differentially in osteoarthritis (OA) cartilage. However, the role it plays in OA pathogenesis is not clear. The aim of this study is to identify a molecular target of miR-146a, thereby elucidating its function in chondrocytes du...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Jing, Huang, Jingang, Dai, Liming, Yu, Degang, Chen, Qian, Zhang, Xiaoling, Dai, Kerong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446449/ https://www.ncbi.nlm.nih.gov/pubmed/22507670 http://dx.doi.org/10.1186/ar3798

Ejemplares similares

miR-146a facilitates osteoarthritis by regulating cartilage homeostasis via targeting Camk2d and Ppp3r2
por: Zhang, Xudong, et al.
Publicado: (2017)

miR-146a, miR-146b, and miR-155 increase expression of IL-6 and IL-8 and support HSP10 in an In vitro sepsis model
por: Pfeiffer, Dagmar, et al.
Publicado: (2017)

miR-146a-5p Regulated Cell Proliferation and Apoptosis by Targeting SMAD3 and SMAD4
por: Qiu, Meiyu, et al.
Publicado: (2020)

Role of miR-146a in human chondrocyte apoptosis in response to mechanical pressure injury in vitro
por: JIN, LEI, et al.
Publicado: (2014)

Circulating miRNAs Are Associated with the Systemic Extent of Atherosclerosis: Novel Observations for miR-27b and miR-146
por: Pereira-da-Silva, Tiago, et al.
Publicado: (2021)

MiR146a modulates chondrogenesis of bone marrow mesenchymal stem cells by modulating Lsm11 expression
por: Liu, Yuhang, et al.
Publicado: (2023)

miR-146a and miR-146b in the diagnosis and prognosis of papillary thyroid carcinoma
por: Qiu, Zhenwei, et al.
Publicado: (2017)

miR-146a promotes cell migration and invasion in melanoma by directly targeting SMAD4
por: Pu, Wei, et al.
Publicado: (2018)

Differential expression of miRNA 155 and miRNA 146a in Parkinson's disease patients
por: Caggiu, Elisa, et al.
Publicado: (2018)

Associations of miRNA-146a and miRNA-223 with Rheumatoid Arthritis and Their Predictive Values
por: Zhang, Haoshaqiang, et al.
Publicado: (2023)

Epigenetic Modulation of Class-Switch DNA Recombination to IgA by miR-146a Through Downregulation of Smad2, Smad3 and Smad4
por: Casali, Paolo, et al.
Publicado: (2021)

MiR-146 and miR-125 in the regulation of innate immunity and inflammation
por: Lee, Hye-Mi, et al.
Publicado: (2016)

Effect of miR-146a and miR-155 on cardiac xenotransplantation
por: Zhao, Zhicheng, et al.
Publicado: (2016)

Analysis of miRNA signatures in CSF identifies upregulation of miR-21 and miR-146a/b in patients with multiple sclerosis and active lesions
por: Muñoz-San Martín, María, et al.
Publicado: (2019)

Involvement of inflammation-related miR-155 and miR-146a in diabetic nephropathy: implications for glomerular endothelial injury
por: Huang, Youqun, et al.
Publicado: (2014)

MiR-146a in Immunity and Disease
por: Rusca, Nicole, et al.
Publicado: (2011)

Use of miRNA Sequencing to Reveal Hub miRNAs and the Effect of miR-582-3p/SMAD2 in the Progression of Hepatocellular Carcinoma
por: Zhao, Yi, et al.
Publicado: (2022)

Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b
por: Cho, Sunglim, et al.
Publicado: (2018)

Exosomal miRNA Expression Profiling and the Roles of Exosomal miR-4741, miR-32, miR-3149, and miR-6727 on Gastric Cancer Progression
por: Tang, Guojun, et al.
Publicado: (2022)

miR-155 and miR-146a collectively regulate meningitic Escherichia coli infection-mediated neuroinflammatory responses
por: Yang, Bo, et al.
Publicado: (2021)

miR-146b-5p promotes the neural conversion of pluripotent stem cells by targeting Smad4
por: Zhang, Nianping, et al.
Publicado: (2017)

Epigenetic control of epileptogenesis by miR-146a
por: Iori, Valentina, et al.
Publicado: (2017)

The clinical significance of circulating miR-21, miR-142, miR-143, and miR-146a in patients with prostate cancer
por: Bolayırlı, Ibrahim Murat, et al.
Publicado: (2022)

Association between Ankylosing Spondylitis and the miR-146a and miR-499 Polymorphisms
por: Xu, Hui Ying, et al.
Publicado: (2015)

MiR-146a and miR-155 polymorphisms in Egyptian patients with Behcet’s disease
por: Shaker, Olfat G., et al.
Publicado: (2021)

Differential Expression of miR-146 and miR-155 in Active and Latent Tuberculosis Infection
por: Alijani, Ebrahim, et al.
Publicado: (2023)

miRNA-146a and miRNA-126 as Potential Biomarkers in Patients with Coronary Artery Disease and Generalized Periodontitis
por: Mahendra, Jaideep, et al.
Publicado: (2021)

Circulating levels of miR125a, miR126, and miR146a-5p in patients with obstructive sleep apnea and their relation with markers of endothelial dysfunction
por: Fadaei, Reza, et al.
Publicado: (2023)

Dysregulation of the miR-146a-Smad4 axis impairs osteogenesis of bone mesenchymal stem cells under inflammation
por: Kuang, Wei, et al.
Publicado: (2017)

MiRNA-146a polymorphism increases the odds of malaria in pregnancy
por: van Loon, Welmoed, et al.
Publicado: (2019)

The Role of miRNA-146a and Proinflammatory Cytokines in Carotid Atherosclerosis
por: Huang, Pan, et al.
Publicado: (2020)

MiRNA-146a—A Key Player in Immunity and Diseases
por: Gilyazova, Irina, et al.
Publicado: (2023)

The role of miR-320a and IL-1β in human chondrocyte degradation
por: Jin, Y., et al.
Publicado: (2017)

Genetic Variants miR-126, miR-146a, miR-196a2, and miR-499 in Polycystic Ovary Syndrome
por: Li, R., et al.
Publicado: (2022)

MiR-146a is over-expressed and controls IL-6 production in cystic fibrosis macrophages
por: Luly, Francesco R., et al.
Publicado: (2019)

Diagnostic potential and pathogenic performance of circulating miR-146b, miR-194, and miR-214 in liver fibrosis
por: Aghajanzadeh, Taha, et al.
Publicado: (2023)

MiR-146b-5p functions as a suppressor miRNA and prognosis predictor in non-small cell lung cancer
por: Li, Yongwen, et al.
Publicado: (2017)

miR-146a inhibits mitochondrial dysfunction and myocardial infarction by targeting cyclophilin D
por: Su, Qiang, et al.
Publicado: (2021)

Differential activation and functional specialization of miR-146 and miR-155 in innate immune sensing
por: Schulte, Leon N., et al.
Publicado: (2013)

Acute meningitis in rats is associated with decreased levels of miR132 and miR146a
por: Jagoo, Mubareka, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_m5s4nje54i7gdh4u236u4qc361