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Bone morphogenetic protein-2-induced Wnt/β-catenin signaling pathway activation through enhanced low-density-lipoprotein receptor-related protein 5 catabolic activity contributes to hypertrophy in osteoarthritic chondrocytes

INTRODUCTION: Events normally taking place in the terminal chondrocyte differentiation in the growth plate are also observed during osteoarthritis (OA) development, suggesting that molecules, such as Wnts and bone morphogenetic proteins (BMPs) regulating chondrocyte activity in the growth plate, may...

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Detalles Bibliográficos
Autores principales:	Papathanasiou, Ioanna, Malizos, Konstantinos N, Tsezou, Aspasia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446456/ https://www.ncbi.nlm.nih.gov/pubmed/22513174 http://dx.doi.org/10.1186/ar3805

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