Interleukin-6 regulates anti-arthritic effect of methotrexate via reduction of SLC19A1 expression in a mouse arthritis model

INTRODUCTION: Methotrexate (MTX) enters cells via the reduced folate carrier SLC19A1, suggesting that SLC19A1 is associated with the efficacy of MTX. We here examined the relationship between the efficacy of MTX and the expression of SLC19A1 in glucose 6-phosphate isomerase (GPI)-induced arthritis....

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Detalles Bibliográficos
Autores principales: Hashizume, Misato, Yoshida, Hiroto, Tanaka, Keisuke, Suzuki, Miho, Matsumoto, Isao, Sumida, Takayuki, Mihara, Masahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446470/
https://www.ncbi.nlm.nih.gov/pubmed/22546471
http://dx.doi.org/10.1186/ar3821

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446470/
https://www.ncbi.nlm.nih.gov/pubmed/22546471
http://dx.doi.org/10.1186/ar3821

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