Increased type II collagen cleavage by cathepsin K and collagenase activities with aging and osteoarthritis in human articular cartilage

INTRODUCTION: The intra-helical cleavage of type II collagen by proteases, including collagenases and cathepsin K, is increased with aging and osteoarthritis (OA) in cartilage as determined by immunochemical assays. The distinct sites of collagen cleavage generated by collagenases and cathepsin K in...

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Detalles Bibliográficos
Autores principales: Dejica, Valeria M, Mort, John S, Laverty, Sheila, Antoniou, John, Zukor, David J, Tanzer, Michael, Poole, A Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446490/
https://www.ncbi.nlm.nih.gov/pubmed/22584047
http://dx.doi.org/10.1186/ar3839

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