Anti-tumor necrosis factor therapy improves insulin resistance, beta cell function and insulin signaling in active rheumatoid arthritis patients with high insulin resistance

INTRODUCTION: Prevalence of insulin resistance and the metabolic syndrome has been reported to be high in rheumatoid arthritis (RA) patients. Tumor necrosis factor (TNF), a pro-inflammatory cytokine with a major pathogenetic role in RA, may promote insulin resistance by inducing Ser(312 )phosphoryla...

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Detalles Bibliográficos
Autores principales: Stagakis, Ilias, Bertsias, George, Karvounaris, Stylianos, Kavousanaki, Melina, Virla, Dimitra, Raptopoulou, Amalia, Kardassis, Dimitrios, Boumpas, Dimitrios T, Sidiropoulos, Prodromos I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446524/
https://www.ncbi.nlm.nih.gov/pubmed/22691241
http://dx.doi.org/10.1186/ar3874

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