B-cell depletion therapy in patients with diffuse systemic sclerosis associates with a significant decrease in PDGFR expression and activation in spindle-like cells in the skin

INTRODUCTION: Recently, several studies assessing the clinical efficacy of rituximab (RTX) in systemic sclerosis (SSc) have reported encouraging results. We aimed at exploring whether RTX exerts its beneficial effects on fibrosis through attenuation of platelet-derived growth factor receptor (PDGFR)...

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Detalles Bibliográficos
Autores principales: Daoussis, Dimitrios, Tsamandas, Athanassios C, Liossis, Stamatis-Nick C, Antonopoulos, Ioannis, Karatza, Elli, Yiannopoulos, Georgios, Andonopoulos, Andrew P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446529/
https://www.ncbi.nlm.nih.gov/pubmed/22697462
http://dx.doi.org/10.1186/ar3879

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