Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism

INTRODUCTION: The mechanism by which intra-articular injection of hyaluronan (HA) ameliorates joint pathology is unknown. Animal studies have shown that HA can reduce synovial activation, periarticular fibrosis and cartilage erosion; however, its specific effects on the different cell types involved...

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Detalles Bibliográficos
Autores principales: Li, Jun, Gorski, Daniel J, Anemaet, Wendy, Velasco, Jennifer, Takeuchi, Jun, Sandy, John D, Plaas, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446537/
https://www.ncbi.nlm.nih.gov/pubmed/22721434
http://dx.doi.org/10.1186/ar3887

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