Persistence versus Reversion of 3TC Resistance in HIV-1 Determine the Rate of Emergence of NVP Resistance

When HIV-1 is exposed to lamivudine (3TC) at inhibitory concentrations, resistant variants carrying the reverse transcriptase (RT) substitution M184V emerge rapidly. This substitution confers high-level 3TC resistance and increased RT fidelity. We established a novel in vitro system to study the eff...

Descripción completa

Detalles Bibliográficos
Autores principales: Rath, Barbara A., Olshen, Richard A., Halpern, Jerry, Merigan, Thomas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446758/
https://www.ncbi.nlm.nih.gov/pubmed/23012621
http://dx.doi.org/10.3390/v4081212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446758/
https://www.ncbi.nlm.nih.gov/pubmed/23012621
http://dx.doi.org/10.3390/v4081212

Ejemplares similares