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Persistence versus Reversion of 3TC Resistance in HIV-1 Determine the Rate of Emergence of NVP Resistance

When HIV-1 is exposed to lamivudine (3TC) at inhibitory concentrations, resistant variants carrying the reverse transcriptase (RT) substitution M184V emerge rapidly. This substitution confers high-level 3TC resistance and increased RT fidelity. We established a novel in vitro system to study the eff...

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Detalles Bibliográficos
Autores principales:	Rath, Barbara A., Olshen, Richard A., Halpern, Jerry, Merigan, Thomas C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446758/ https://www.ncbi.nlm.nih.gov/pubmed/23012621 http://dx.doi.org/10.3390/v4081212

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