How the Interval between Prime and Boost Injection Affects the Immune Response in a Computational Model of the Immune System

The immune system is able to respond more vigorously to the second contact with a given antigen than to the first contact. Vaccination protocols generally include at least two doses, in order to obtain high antibody titers. We want to analyze the relation between the time elapsed from the first dose...

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Detalles Bibliográficos
Autores principales: Castiglione, F., Mantile, F., De Berardinis, P., Prisco, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446774/
https://www.ncbi.nlm.nih.gov/pubmed/22997539
http://dx.doi.org/10.1155/2012/842329
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author Castiglione, F.
Mantile, F.
De Berardinis, P.
Prisco, A.
author_facet Castiglione, F.
Mantile, F.
De Berardinis, P.
Prisco, A.
author_sort Castiglione, F.
collection PubMed
description The immune system is able to respond more vigorously to the second contact with a given antigen than to the first contact. Vaccination protocols generally include at least two doses, in order to obtain high antibody titers. We want to analyze the relation between the time elapsed from the first dose (priming) and the second dose (boost) on the antibody titers. In this paper, we couple in vivo experiments with computer simulations to assess the effect of delaying the second injection. We observe that an interval of several weeks between the prime and the boost is necessary to obtain optimal antibody responses.
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spelling pubmed-34467742012-09-20 How the Interval between Prime and Boost Injection Affects the Immune Response in a Computational Model of the Immune System Castiglione, F. Mantile, F. De Berardinis, P. Prisco, A. Comput Math Methods Med Research Article The immune system is able to respond more vigorously to the second contact with a given antigen than to the first contact. Vaccination protocols generally include at least two doses, in order to obtain high antibody titers. We want to analyze the relation between the time elapsed from the first dose (priming) and the second dose (boost) on the antibody titers. In this paper, we couple in vivo experiments with computer simulations to assess the effect of delaying the second injection. We observe that an interval of several weeks between the prime and the boost is necessary to obtain optimal antibody responses. Hindawi Publishing Corporation 2012 2012-09-11 /pmc/articles/PMC3446774/ /pubmed/22997539 http://dx.doi.org/10.1155/2012/842329 Text en Copyright © 2012 F. Castiglione et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Castiglione, F.
Mantile, F.
De Berardinis, P.
Prisco, A.
How the Interval between Prime and Boost Injection Affects the Immune Response in a Computational Model of the Immune System
title How the Interval between Prime and Boost Injection Affects the Immune Response in a Computational Model of the Immune System
title_full How the Interval between Prime and Boost Injection Affects the Immune Response in a Computational Model of the Immune System
title_fullStr How the Interval between Prime and Boost Injection Affects the Immune Response in a Computational Model of the Immune System
title_full_unstemmed How the Interval between Prime and Boost Injection Affects the Immune Response in a Computational Model of the Immune System
title_short How the Interval between Prime and Boost Injection Affects the Immune Response in a Computational Model of the Immune System
title_sort how the interval between prime and boost injection affects the immune response in a computational model of the immune system
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446774/
https://www.ncbi.nlm.nih.gov/pubmed/22997539
http://dx.doi.org/10.1155/2012/842329
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