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Formation and Regulation of Adaptive Response in Nematode Caenorhabditis elegans
All organisms respond to environmental stresses (e.g., heavy metal, heat, UV irradiation, hyperoxia, food limitation, etc.) with coordinated adjustments in order to deal with the consequences and/or injuries caused by the severe stress. The nematode Caenorhabditis elegans often exerts adaptive respo...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446806/ https://www.ncbi.nlm.nih.gov/pubmed/22997543 http://dx.doi.org/10.1155/2012/564093 |
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author | Zhao, Y.-L. Wang, D.-Y. |
author_facet | Zhao, Y.-L. Wang, D.-Y. |
author_sort | Zhao, Y.-L. |
collection | PubMed |
description | All organisms respond to environmental stresses (e.g., heavy metal, heat, UV irradiation, hyperoxia, food limitation, etc.) with coordinated adjustments in order to deal with the consequences and/or injuries caused by the severe stress. The nematode Caenorhabditis elegans often exerts adaptive responses if preconditioned with low concentrations of agents or stressor. In C. elegans, three types of adaptive responses can be formed: hormesis, cross-adaptation, and dietary restriction. Several factors influence the formation of adaptive responses in nematodes, and some mechanisms can explain their response formation. In particular, antioxidation system, heat-shock proteins, metallothioneins, glutathione, signaling transduction, and metabolic signals may play important roles in regulating the formation of adaptive responses. In this paper, we summarize the published evidence demonstrating that several types of adaptive responses have converged in C. elegans and discussed some possible alternative theories explaining the adaptive response control. |
format | Online Article Text |
id | pubmed-3446806 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34468062012-09-20 Formation and Regulation of Adaptive Response in Nematode Caenorhabditis elegans Zhao, Y.-L. Wang, D.-Y. Oxid Med Cell Longev Review Article All organisms respond to environmental stresses (e.g., heavy metal, heat, UV irradiation, hyperoxia, food limitation, etc.) with coordinated adjustments in order to deal with the consequences and/or injuries caused by the severe stress. The nematode Caenorhabditis elegans often exerts adaptive responses if preconditioned with low concentrations of agents or stressor. In C. elegans, three types of adaptive responses can be formed: hormesis, cross-adaptation, and dietary restriction. Several factors influence the formation of adaptive responses in nematodes, and some mechanisms can explain their response formation. In particular, antioxidation system, heat-shock proteins, metallothioneins, glutathione, signaling transduction, and metabolic signals may play important roles in regulating the formation of adaptive responses. In this paper, we summarize the published evidence demonstrating that several types of adaptive responses have converged in C. elegans and discussed some possible alternative theories explaining the adaptive response control. Hindawi Publishing Corporation 2012 2012-09-11 /pmc/articles/PMC3446806/ /pubmed/22997543 http://dx.doi.org/10.1155/2012/564093 Text en Copyright © 2012 Y.-L. Zhao and D.-Y. Wang. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zhao, Y.-L. Wang, D.-Y. Formation and Regulation of Adaptive Response in Nematode Caenorhabditis elegans |
title | Formation and Regulation of Adaptive Response in Nematode Caenorhabditis elegans
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title_full | Formation and Regulation of Adaptive Response in Nematode Caenorhabditis elegans
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title_fullStr | Formation and Regulation of Adaptive Response in Nematode Caenorhabditis elegans
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title_full_unstemmed | Formation and Regulation of Adaptive Response in Nematode Caenorhabditis elegans
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title_short | Formation and Regulation of Adaptive Response in Nematode Caenorhabditis elegans
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title_sort | formation and regulation of adaptive response in nematode caenorhabditis elegans |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446806/ https://www.ncbi.nlm.nih.gov/pubmed/22997543 http://dx.doi.org/10.1155/2012/564093 |
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